Gene: B0336.8
B0336.8 | Evidence | CGC_data_submission | ||||
---|---|---|---|---|---|---|
SMap | S_parent | Sequence | B0336 | |||
Chromosome | III | |||||
Identity (5) | ||||||
Gene_info | Gene_class | lgg | ||||
Allele | tm1642 | |||||
GO_term | GO:0000045 | IEA | Inferred_automatically | |||
GO:0005737 | IEA | Inferred_automatically | ||||
Contained_in_operon | CEOP3324 | |||||
Structured_description | Provisional_description | lgg-3 encodes a hydrophilic protein that is orthologous to Saccharomyces cerevisiae autophagy protein Apg12p; by homology, LGG-3 is predicted to function as a modifier protein required for a protein conjugation system essential for autophagy; in the context of this conjugation system, LGG-3 is predicted to interact with Apg7p and Apg5p homologs (encoded by M7.5 and Y71G12B.12a, respectively) to effect bulk degradation of cytoplasmic components under conditions of starvation or cellular remodeling; free LGG-3 is predicted to localize to the cytoplasm, while LGG-3 conjugated to the Apg5p homolog is predicted to associate with membrane compartments; loss of lgg-3 activity via large-scale RNAi screens results in no obvious developmental or behavioral abnormalities. | Paper_evidence | WBPaper00004403 | ||
WBPaper00005654 | ||||||
WBPaper00013631 | ||||||
Person_evidence | WBPerson1843 | |||||
Curator_confirmed | WBPerson1843 | |||||
Date_last_updated | 17 Jun 2004 00:00:00 | |||||
Concise_description | lgg-3 encodes a hydrophilic protein that is orthologous to Saccharomyces cerevisiae autophagy protein Apg12p; by homology, LGG-3 is predicted to function as a modifier protein required for a protein conjugation system essential for autophagy; in the context of this conjugation system, LGG-3 is predicted to interact with Apg7p and Apg5p homologs (encoded by M7.5 and Y71G12B.12a, respectively) to effect bulk degradation of cytoplasmic components under conditions of starvation or cellular remodeling; free LGG-3 is predicted to localize to the cytoplasm, while LGG-3 conjugated to the Apg5p homolog is predicted to associate with membrane compartments; loss of lgg-3 activity via large-scale RNAi screens results in no obvious developmental or behavioral abnormalities. | |||||
Molecular_info (5) | ||||||
Experimental_info | RNAi_result | Cenix:230-c1 | ||||
Cenix:310-d5 | ||||||
Cenix:310-e10 | ||||||
Cenix:329-c6 | ||||||
JA:B0336.8 | ||||||
TH:310D5 | ||||||
TH:310E10 | ||||||
TH:329C6 | ||||||
WB_RNAi_result (9) | ||||||
Reference | WBPaper00026086 | |||||
Remark | Sequence connection from [Kimura Y] | |||||
Method | Gene |