B0336.8 | Evidence | CGC_data_submission |
| SMap | S_parent | Sequence | B0336
|
| Chromosome | III |
|
Identity
| Version | 1 |
| |
Name (7)
|
| | Species | Caenorhabditis elegans
|
| | History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971
| Event | Imported | Initial conversion from geneace |
| | Status | Live |
|
Gene_info
| Gene_class | lgg
|
| | Allele | tm1642
|
| |
GO_term
| GO:0000045
| IEA
| Inferred_automatically |
| | | GO:0005737
| IEA
| Inferred_automatically |
| | Contained_in_operon | CEOP3324
|
| |
Structured_description
| Provisional_description | lgg-3 encodes a hydrophilic protein that is orthologous to Saccharomyces cerevisiae autophagy protein Apg12p; by homology, LGG-3 is predicted to function as a modifier protein required for a protein conjugation system essential for autophagy; in the context of this conjugation system, LGG-3 is predicted to interact with Apg7p and Apg5p homologs (encoded by M7.5 and Y71G12B.12a, respectively) to effect bulk degradation of cytoplasmic components under conditions of starvation or cellular remodeling; free LGG-3 is predicted to localize to the cytoplasm, while LGG-3 conjugated to the Apg5p homolog is predicted to associate with membrane compartments; loss of lgg-3 activity via large-scale RNAi screens results in no obvious developmental or behavioral abnormalities. |
Paper_evidence
| WBPaper00004403
|
| | | | | | WBPaper00005654
|
| | | | | | WBPaper00013631
|
| | | | | Person_evidence | WBPerson1843
|
| | | | | Curator_confirmed | WBPerson1843
|
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Concise_description | lgg-3 encodes a hydrophilic protein that is orthologous to Saccharomyces cerevisiae autophagy protein Apg12p; by homology, LGG-3 is predicted to function as a modifier protein required for a protein conjugation system essential for autophagy; in the context of this conjugation system, LGG-3 is predicted to interact with Apg7p and Apg5p homologs (encoded by M7.5 and Y71G12B.12a, respectively) to effect bulk degradation of cytoplasmic components under conditions of starvation or cellular remodeling; free LGG-3 is predicted to localize to the cytoplasm, while LGG-3 conjugated to the Apg5p homolog is predicted to associate with membrane compartments; loss of lgg-3 activity via large-scale RNAi screens results in no obvious developmental or behavioral abnormalities. |
|
Molecular_info (5)
|
|
Experimental_info
|
RNAi_result (8)
|
| |
WB_RNAi_result (9)
|
| Reference | WBPaper00026086
|
| Remark | Sequence connection from [Kimura Y] |
| Method | Gene
|