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Gene: B0348.6   

B0348.6SMapS_parentSequenceB0348
ChromosomeV
Identity (5)
Gene_info Gene_classife
Alleleok191 Inferred_automaticallyFrom strain object: KX10
Phenotype[Aamodt EJ] ife for Initiation Factor E family. No mutants known.
StrainKX10
GO_term GO:0003723 IEA Inferred_automatically
GO:0003743 IEA Inferred_automatically
GO:0006413 IEA Inferred_automatically
GO:0005737 IEA Inferred_automatically
Structured_description Provisional_descriptionife-3 encodes one of five C. elegans homologs of the mRNA cap-binding protein eIF4E; by homology, IFE-3 is predicted to bind capped mRNA and mediate its recruitment to ribosomes during translation initiation; in vitro, IFE-3 binds a monomethylated guanosine cap structure but does not bind a trimethylated guanosine cap, which suggests that IFE-3 likely mediates translation of those mRNAs that do not contain a spliced-leader sequence; of the C. elegans eIF4E isoforms, IFE-3 is the most similar to human eIF4E and is the only isoform required for viability (homozygous ife-3 mutant embryos arrest in the early division stages of embryogenesis); IFE-3 is enriched in the adult gonad. Paper_evidence WBPaper00003987
WBPaper00005444
WBPaper00005497
WBPaper00017674
Person_evidenceWBPerson1843
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
Concise_descriptionife-3 encodes one of five C. elegans homologs of the mRNA cap-binding protein eIF4E; by homology, IFE-3 is predicted to bind capped mRNA and mediate its recruitment to ribosomes during translation initiation; in vitro, IFE-3 binds a monomethylated guanosine cap structure but does not bind a trimethylated guanosine cap, which suggests that IFE-3 likely mediates translation of those mRNAs that do not contain a spliced-leader sequence; of the C. elegans eIF4E isoforms, IFE-3 is the most similar to human eIF4E and is the only isoform required for viability (homozygous ife-3 mutant embryos arrest in the early division stages of embryogenesis); IFE-3 is enriched in the adult gonad.
Molecular_info Corresponding_CDS B0348.6a
B0348.6b
B0348.6c
Corresponding_protein WP:CE17331
WP:CE27570
WP:CE30590
Corresponding_PCR_product sjj_B0348.6
sjj_Y108G3B.a
Corresponding_RNAi_reagent Cenix:30-d4
Cenix:145-e8
sjj_B0348.6
mv_B0348.6
Experimental_info RNAi_result Cenix:145-e8
Cenix:30-d4
JA:B0348.6
WB_RNAi_result JA:B0348.6
MV_SV:mv_B0348.6
Cenix:145-e8
Cenix:30-d4
Expr_patternExpr2325
Y2H_target (20)
Reference (6)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene