Gene: B0348.6
B0348.6 | SMap | S_parent | Sequence | B0348 | |||||
---|---|---|---|---|---|---|---|---|---|
Chromosome | V | ||||||||
Identity | Version | 1 | |||||||
Name (7) | |||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Gene_class | ife | |||||||
Allele | ok191 | Inferred_automatically | From strain object: KX10 | ||||||
Phenotype | [Aamodt EJ] ife for Initiation Factor E family. No mutants known. | ||||||||
Strain | KX10 | ||||||||
GO_term | GO:0003723 | IEA | Inferred_automatically | ||||||
GO:0003743 | IEA | Inferred_automatically | |||||||
GO:0006413 | IEA | Inferred_automatically | |||||||
GO:0005737 | IEA | Inferred_automatically | |||||||
Structured_description | Provisional_description | ife-3 encodes one of five C. elegans homologs of the mRNA cap-binding protein eIF4E; by homology, IFE-3 is predicted to bind capped mRNA and mediate its recruitment to ribosomes during translation initiation; in vitro, IFE-3 binds a monomethylated guanosine cap structure but does not bind a trimethylated guanosine cap, which suggests that IFE-3 likely mediates translation of those mRNAs that do not contain a spliced-leader sequence; of the C. elegans eIF4E isoforms, IFE-3 is the most similar to human eIF4E and is the only isoform required for viability (homozygous ife-3 mutant embryos arrest in the early division stages of embryogenesis); IFE-3 is enriched in the adult gonad. | Paper_evidence | WBPaper00003987 | |||||
WBPaper00005444 | |||||||||
WBPaper00005497 | |||||||||
WBPaper00017674 | |||||||||
Person_evidence | WBPerson1843 | ||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
Concise_description | ife-3 encodes one of five C. elegans homologs of the mRNA cap-binding protein eIF4E; by homology, IFE-3 is predicted to bind capped mRNA and mediate its recruitment to ribosomes during translation initiation; in vitro, IFE-3 binds a monomethylated guanosine cap structure but does not bind a trimethylated guanosine cap, which suggests that IFE-3 likely mediates translation of those mRNAs that do not contain a spliced-leader sequence; of the C. elegans eIF4E isoforms, IFE-3 is the most similar to human eIF4E and is the only isoform required for viability (homozygous ife-3 mutant embryos arrest in the early division stages of embryogenesis); IFE-3 is enriched in the adult gonad. | ||||||||
Molecular_info | Corresponding_CDS | B0348.6a | |||||||
B0348.6b | |||||||||
B0348.6c | |||||||||
Corresponding_protein | WP:CE17331 | ||||||||
WP:CE27570 | |||||||||
WP:CE30590 | |||||||||
Corresponding_PCR_product | sjj_B0348.6 | ||||||||
sjj_Y108G3B.a | |||||||||
Corresponding_RNAi_reagent | Cenix:30-d4 | ||||||||
Cenix:145-e8 | |||||||||
sjj_B0348.6 | |||||||||
mv_B0348.6 | |||||||||
Experimental_info | RNAi_result | Cenix:145-e8 | |||||||
Cenix:30-d4 | |||||||||
JA:B0348.6 | |||||||||
WB_RNAi_result | JA:B0348.6 | ||||||||
MV_SV:mv_B0348.6 | |||||||||
Cenix:145-e8 | |||||||||
Cenix:30-d4 | |||||||||
Expr_pattern | Expr2325 | ||||||||
Y2H_target (20) | |||||||||
Reference (6) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |