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Gene: B0348.6 
| B0348.6 | SMap | S_parent | Sequence | B0348 | ||
|---|---|---|---|---|---|---|
| Chromosome | V | |||||
| Identity (5) | ||||||
| Gene_info | Gene_class | ife | ||||
| Allele | ok191 | Inferred_automatically | From strain object: KX10 | |||
| Phenotype | [Aamodt EJ] ife for Initiation Factor E family. No mutants known. | |||||
| Strain | KX10 | |||||
| GO_term | GO:0003723 | IEA | Inferred_automatically | |||
| GO:0003743 | IEA | Inferred_automatically | ||||
| GO:0006413 | IEA | Inferred_automatically | ||||
| GO:0005737 | IEA | Inferred_automatically | ||||
| Structured_description | Provisional_description | ife-3 encodes one of five C. elegans homologs of the mRNA cap-binding protein eIF4E; by homology, IFE-3 is predicted to bind capped mRNA and mediate its recruitment to ribosomes during translation initiation; in vitro, IFE-3 binds a monomethylated guanosine cap structure but does not bind a trimethylated guanosine cap, which suggests that IFE-3 likely mediates translation of those mRNAs that do not contain a spliced-leader sequence; of the C. elegans eIF4E isoforms, IFE-3 is the most similar to human eIF4E and is the only isoform required for viability (homozygous ife-3 mutant embryos arrest in the early division stages of embryogenesis); IFE-3 is enriched in the adult gonad. | Paper_evidence | WBPaper00003987 | ||
| WBPaper00005444 | ||||||
| WBPaper00005497 | ||||||
| WBPaper00017674 | ||||||
| Person_evidence | WBPerson1843 | |||||
| Curator_confirmed | WBPerson1843 | |||||
| Date_last_updated | 17 Jun 2004 00:00:00 | |||||
| Concise_description | ife-3 encodes one of five C. elegans homologs of the mRNA cap-binding protein eIF4E; by homology, IFE-3 is predicted to bind capped mRNA and mediate its recruitment to ribosomes during translation initiation; in vitro, IFE-3 binds a monomethylated guanosine cap structure but does not bind a trimethylated guanosine cap, which suggests that IFE-3 likely mediates translation of those mRNAs that do not contain a spliced-leader sequence; of the C. elegans eIF4E isoforms, IFE-3 is the most similar to human eIF4E and is the only isoform required for viability (homozygous ife-3 mutant embryos arrest in the early division stages of embryogenesis); IFE-3 is enriched in the adult gonad. | |||||
| Molecular_info | Corresponding_CDS | B0348.6a | ||||
| B0348.6b | ||||||
| B0348.6c | ||||||
| Corresponding_protein | WP:CE17331 | |||||
| WP:CE27570 | ||||||
| WP:CE30590 | ||||||
| Corresponding_PCR_product | sjj_B0348.6 | |||||
| sjj_Y108G3B.a | ||||||
| Corresponding_RNAi_reagent | Cenix:30-d4 | |||||
| Cenix:145-e8 | ||||||
| sjj_B0348.6 | ||||||
| mv_B0348.6 | ||||||
| Experimental_info | RNAi_result | Cenix:145-e8 | ||||
| Cenix:30-d4 | ||||||
| JA:B0348.6 | ||||||
| WB_RNAi_result | JA:B0348.6 | |||||
| MV_SV:mv_B0348.6 | ||||||
| Cenix:145-e8 | ||||||
| Cenix:30-d4 | ||||||
| Expr_pattern | Expr2325 | |||||
| Y2H_target (20) | ||||||
| Reference | WBPaper00017674 | |||||
| WBPaper00003054 | ||||||
| WBPaper00003987 | ||||||
| WBPaper00005444 | ||||||
| WBPaper00023303 | ||||||
| WBPaper00005497 | ||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||
| Method | Gene |
