B0348.6 | SMap | S_parent | Sequence | B0348
|
| Chromosome | V |
|
Identity (5)
|
|
Gene_info
| Gene_class | ife
|
| | Allele | ok191
| Inferred_automatically | From strain object: KX10 |
| | Phenotype | [Aamodt EJ] ife for Initiation Factor E family. No mutants known. |
| | Strain | KX10
|
| |
GO_term
| GO:0003723
| IEA
| Inferred_automatically |
| | | GO:0003743
| IEA
| Inferred_automatically |
| | | GO:0006413
| IEA
| Inferred_automatically |
| | | GO:0005737
| IEA
| Inferred_automatically |
| |
Structured_description
| Provisional_description | ife-3 encodes one of five C. elegans homologs of the mRNA cap-binding protein eIF4E; by homology, IFE-3 is predicted to bind capped mRNA and mediate its recruitment to ribosomes during translation initiation; in vitro, IFE-3 binds a monomethylated guanosine cap structure but does not bind a trimethylated guanosine cap, which suggests that IFE-3 likely mediates translation of those mRNAs that do not contain a spliced-leader sequence; of the C. elegans eIF4E isoforms, IFE-3 is the most similar to human eIF4E and is the only isoform required for viability (homozygous ife-3 mutant embryos arrest in the early division stages of embryogenesis); IFE-3 is enriched in the adult gonad. |
Paper_evidence
| WBPaper00003987
|
| | | | | | WBPaper00005444
|
| | | | | | WBPaper00005497
|
| | | | | | WBPaper00017674
|
| | | | | Person_evidence | WBPerson1843
|
| | | | | Curator_confirmed | WBPerson1843
|
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Concise_description | ife-3 encodes one of five C. elegans homologs of the mRNA cap-binding protein eIF4E; by homology, IFE-3 is predicted to bind capped mRNA and mediate its recruitment to ribosomes during translation initiation; in vitro, IFE-3 binds a monomethylated guanosine cap structure but does not bind a trimethylated guanosine cap, which suggests that IFE-3 likely mediates translation of those mRNAs that do not contain a spliced-leader sequence; of the C. elegans eIF4E isoforms, IFE-3 is the most similar to human eIF4E and is the only isoform required for viability (homozygous ife-3 mutant embryos arrest in the early division stages of embryogenesis); IFE-3 is enriched in the adult gonad. |
|
Molecular_info
|
Corresponding_CDS
| B0348.6a
|
| | | B0348.6b
|
| | | B0348.6c
|
| |
Corresponding_protein
| WP:CE17331
|
| | | WP:CE27570
|
| | | WP:CE30590
|
| |
Corresponding_PCR_product
| sjj_B0348.6
|
| | | sjj_Y108G3B.a
|
| |
Corresponding_RNAi_reagent
| Cenix:30-d4
|
| | | Cenix:145-e8
|
| | | sjj_B0348.6
|
| | | mv_B0348.6
|
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Experimental_info (4)
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Reference (6)
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| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene
|