B0379.3 | Evidence | Person_evidence | WBPerson490
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| SMap | S_parent | Sequence | B0379
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| Chromosome | I |
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Identity
| Version | 1 |
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Name (7)
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| | Species | Caenorhabditis elegans
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| | History | Version_change | 1 | 07 Apr 2004 11:29:32 | WBPerson1971
| Event | Imported | Initial conversion from geneace |
| | Status | Live |
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Gene_info
| Gene_class | mut
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GO_term (5)
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Structured_description
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Provisional_description
| mut-16 encodes a glutamine/asparagine (Q/N)-rich domain-containing protein that lacks obvious homologs outside of other nematode species; MUT-16 activity is required for RNA-mediated interference (RNAi), transgene silencing in germ-line and somatic tissues, and for maintaining low levels of transposon mobilization; MUT-16 is thus predicted to play a role in chromatin organizataion and/or regulation of gene expression. |
Paper_evidence (7)
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| | | | | Person_evidence | WBPerson1843
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| | | | | Curator_confirmed | WBPerson1843
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| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | | The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77). |
| | | | Proteins bearing such domains can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. |
| | | | Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya. |
| | | | Therefore, it is possible that this gene's protein product undergoes epigenetic control of protein activity, through heritable epigenetic modulation of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. |
| | | | It is important to note that this is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. |
| | | Concise_description | mut-16 encodes a glutamine/asparagine (Q/N)-rich domain-containing protein that lacks obvious homologs outside of other nematode species; MUT-16 activity is required for RNA-mediated interference (RNAi), transgene silencing in germ-line and somatic tissues, and for maintaining low levels of transposon mobilization; MUT-16 is thus predicted to play a role in chromatin organizataion and/or regulation of gene expression. |
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Molecular_info (5)
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Experimental_info
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RNAi_result
| Cenix:145-f8
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| | | Cenix:18-e1
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| | | JA:B0379.3
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WB_RNAi_result
| JA:B0379.3
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| | | Cenix:145-f8
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| | | Cenix:18-e1
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| | Interaction | WBInteraction0002320
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Reference (10)
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| Method | Gene
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