B0464.5 | SMap | S_parent | Sequence | SUPERLINK_CB_IIIR
|
| Chromosome | III |
|
Identity (5)
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Gene_info
| Gene_class | spk
|
| | Allele | ok706
| Inferred_automatically | From strain object: VC638 |
| |
Strain
| NL742
|
| | | VC638
|
| |
Structured_description
| Provisional_description | spk-1 encodes a serine/threonine kinase orthologous to the highly conserved serine/arginine-rich protein kinases (SRPKs) that phosphorylate SR proteins, essential components of the pre-mRNA splicing machinery; SPK-1, required for embryogenesis and germline development, can directly bind and phosphorylate RSP-3 (CeSF2/ASF), an SR splicing factor homolog; SPK-1 is expressed predominantly in the adult germline; SPK-1 is homologous to human RSK2, which when mutated leads to Coffin-Lowry syndrome (OMIM:303600). |
Paper_evidence
| WBPaper00004103
|
| | | | | | WBPaper00004476
|
| | | | | Person_evidence | WBPerson1843
|
| | | | | Curator_confirmed | WBPerson1843
|
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Concise_description | spk-1 encodes a serine/threonine kinase orthologous to the highly conserved serine/arginine-rich protein kinases (SRPKs) that phosphorylate SR proteins, essential components of the pre-mRNA splicing machinery; SPK-1, required for embryogenesis and germline development, can directly bind and phosphorylate RSP-3 (CeSF2/ASF), an SR splicing factor homolog; SPK-1 is expressed predominantly in the adult germline; SPK-1 is homologous to human RSK2, which when mutated leads to Coffin-Lowry syndrome (OMIM:303600). |
|
Molecular_info
|
Corresponding_CDS
| B0464.5a
|
| | | B0464.5b
|
| | | B0464.5c
|
| |
Corresponding_CDS_history
| B0464.5a:wp123
|
| | | B0464.5c:wp119
|
| |
Corresponding_protein
| WP:CE20457
|
| | | WP:CE36373
|
| | | WP:CE36580
|
| | KOG | KOG1290
|
| |
Corresponding_PCR_product
| smd_B0464.5
|
| | | sjj_B0464.5
|
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Corresponding_RNAi_reagent (5)
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Experimental_info (5)
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Reference
| WBPaper00018645
|
| | WBPaper00003988
|
| | WBPaper00004476
|
| | WBPaper00010108
|
|
Remark
| The srk-1 gene was merged into this gene following advice by Jonathan Hodgkin. srk-1 was connected to different sequences which may have been in error and these sequence connections have been removed from the merged gene. krb 27/02/02 |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene
|