B0464.5 | SMap | S_parent | Sequence | SUPERLINK_CB_IIIR
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| Chromosome | III |
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Identity (5)
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Gene_info
| Gene_class | spk
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| | Allele | ok706
| Inferred_automatically | From strain object: VC638 |
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Strain
| NL742
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| | | VC638
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Structured_description
| Provisional_description | spk-1 encodes a serine/threonine kinase orthologous to the highly conserved serine/arginine-rich protein kinases (SRPKs) that phosphorylate SR proteins, essential components of the pre-mRNA splicing machinery; SPK-1, required for embryogenesis and germline development, can directly bind and phosphorylate RSP-3 (CeSF2/ASF), an SR splicing factor homolog; SPK-1 is expressed predominantly in the adult germline; SPK-1 is homologous to human RSK2, which when mutated leads to Coffin-Lowry syndrome (OMIM:303600). |
Paper_evidence
| WBPaper00004103
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| | | | | | WBPaper00004476
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| | | | | Person_evidence | WBPerson1843
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| | | | | Curator_confirmed | WBPerson1843
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| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Concise_description | spk-1 encodes a serine/threonine kinase orthologous to the highly conserved serine/arginine-rich protein kinases (SRPKs) that phosphorylate SR proteins, essential components of the pre-mRNA splicing machinery; SPK-1, required for embryogenesis and germline development, can directly bind and phosphorylate RSP-3 (CeSF2/ASF), an SR splicing factor homolog; SPK-1 is expressed predominantly in the adult germline; SPK-1 is homologous to human RSK2, which when mutated leads to Coffin-Lowry syndrome (OMIM:303600). |
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Molecular_info (6)
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Experimental_info (5)
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Reference (4)
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Remark
| The srk-1 gene was merged into this gene following advice by Jonathan Hodgkin. srk-1 was connected to different sequences which may have been in error and these sequence connections have been removed from the merged gene. krb 27/02/02 |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene
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