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Gene: B0464.5 
| B0464.5 | SMap | S_parent | Sequence | SUPERLINK_CB_IIIR | ||
|---|---|---|---|---|---|---|
| Chromosome | III | |||||
| Identity (5) | ||||||
| Gene_info | Gene_class | spk | ||||
| Allele | ok706 | Inferred_automatically | From strain object: VC638 | |||
| Strain | NL742 | |||||
| VC638 | ||||||
| Structured_description | Provisional_description | spk-1 encodes a serine/threonine kinase orthologous to the highly conserved serine/arginine-rich protein kinases (SRPKs) that phosphorylate SR proteins, essential components of the pre-mRNA splicing machinery; SPK-1, required for embryogenesis and germline development, can directly bind and phosphorylate RSP-3 (CeSF2/ASF), an SR splicing factor homolog; SPK-1 is expressed predominantly in the adult germline; SPK-1 is homologous to human RSK2, which when mutated leads to Coffin-Lowry syndrome (OMIM:303600). | Paper_evidence | WBPaper00004103 | ||
| WBPaper00004476 | ||||||
| Person_evidence | WBPerson1843 | |||||
| Curator_confirmed | WBPerson1843 | |||||
| Date_last_updated | 17 Jun 2004 00:00:00 | |||||
| Concise_description | spk-1 encodes a serine/threonine kinase orthologous to the highly conserved serine/arginine-rich protein kinases (SRPKs) that phosphorylate SR proteins, essential components of the pre-mRNA splicing machinery; SPK-1, required for embryogenesis and germline development, can directly bind and phosphorylate RSP-3 (CeSF2/ASF), an SR splicing factor homolog; SPK-1 is expressed predominantly in the adult germline; SPK-1 is homologous to human RSK2, which when mutated leads to Coffin-Lowry syndrome (OMIM:303600). | |||||
| Molecular_info (6) | ||||||
| Experimental_info (5) | ||||||
| Reference | WBPaper00018645 | |||||
| WBPaper00003988 | ||||||
| WBPaper00004476 | ||||||
| WBPaper00010108 | ||||||
| Remark (2) | ||||||
| Method | Gene |
