RNAiDB Tree View

Gene: C01G6.8

C01G6.8	Evidence	CGC_data_submission
	SMap	S_parent	Sequence	SUPERLINK_CB_II
	Chromosome	II
	Identity (5)
	Gene_info	Gene_class	cam
		Allele (11)
		Phenotype	[Forrester WC] gm122 homozygotes are 87% Unc (exaggerated waveform, often coiling), sometimes withered tail, weak Daf-c. OA1: gm105 (weaker phenotypes).
			[C.elegansII] NMK. Encodes transmembrane kinase of trk/NGFR class; contains Kringle domain. [FK]
		Strain	FK163
			NG2615
			WF1131
		GO_term (12)
		Structured_description	Provisional_description	The cam-1 gene encodes a receptor tyrosine kinase of the immunoglobulin superfamily that is orthologous to human ROR1 (OMIM:602336) and ROR2 (OMIM:602337, mutation of which leads to type B brachydactyly) and is required for locomotion, cell migration, asymmetric cell division, axon outgrowth, and dauer formation; CAM-1 is broadly expressed during embryogenesis and larval development with expression first appearing at the 200-cell stage of embryogenesis.	Paper_evidence (6)
					Person_evidence	WBPerson1843
					Curator_confirmed	WBPerson1843
					Date_last_updated	17 Jun 2004 00:00:00
			Concise_description	The cam-1 gene encodes a receptor tyrosine kinase of the immunoglobulin superfamily that is orthologous to human ROR1 (OMIM:602336) and ROR2 (OMIM:602337, mutation of which leads to type B brachydactyly) and is required for locomotion, cell migration, asymmetric cell division, axon outgrowth, and dauer formation; CAM-1 is broadly expressed during embryogenesis and larval development with expression first appearing at the 200-cell stage of embryogenesis.
	Molecular_info (6)
	Experimental_info	RNAi_result (8)
		WB_RNAi_result (9)
		Expr_pattern	Expr1146
			Expr2266
			Expr2267
			Expr2268
		Interaction	WBInteraction0000989
			WBInteraction0000990
			WBInteraction0003289
	Reference (36)
	Remark	Data extracted from Forrester et al. (1998)
		Sequence connection from [Poulson S, Maricq AV]
		old_name kin-8 becomes new_name cam-1 from [Poulson S, Maricq AV].
	Method	Gene