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Gene: C02F5.1   

C02F5.1SMapS_parentSequenceC02F5
ChromosomeIII
Identity (5)
Gene_info Gene_classknl
Structured_description Provisional_descriptionknl-1 encodes a novel acidic protein with a coiled-coil region at its C-terminus; KNL-1 is an essential kinetochore component that is required for proper spindle elongation and chromosome separation, and in the kinetochore assembly pathway, plays a key role in linking the initiation of kinetochore formation with the construction of a functional microtubule-binding interface; in the assembly pathway, KNL-1 functions downstream of the DNA-proximal kinetochore components CeCENP-A/HCP-3 and CeCENP-B/HCP-4 and upstream of the outer kinetochore components HIM-10/Nuf2p, NDC-80/HEC1, CeBUB-1, HCP-1, and CeCLASP2/CLS-2; in expression studies in the one-cell embryo, KNL-1 localizes to kinetochores throughout mitosis. Paper_evidence WBPaper00004403
WBPaper00006142
Person_evidenceWBPerson1843
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
Concise_descriptionknl-1 encodes a novel acidic protein with a coiled-coil region at its C-terminus; KNL-1 is an essential kinetochore component that is required for proper spindle elongation and chromosome separation, and in the kinetochore assembly pathway, plays a key role in linking the initiation of kinetochore formation with the construction of a functional microtubule-binding interface; in the assembly pathway, KNL-1 functions downstream of the DNA-proximal kinetochore components CeCENP-A/HCP-3 and CeCENP-B/HCP-4 and upstream of the outer kinetochore components HIM-10/Nuf2p, NDC-80/HEC1, CeBUB-1, HCP-1, and CeCLASP2/CLS-2; in expression studies in the one-cell embryo, KNL-1 localizes to kinetochores throughout mitosis.
Molecular_info Corresponding_CDSC02F5.1
Corresponding_proteinWP:CE02450
Corresponding_PCR_product smd_C02F5.1
sjj_C02F5.1
Corresponding_RNAi_reagent (7)
Experimental_info RNAi_result (5)
WB_RNAi_result (7)
Expr_pattern Expr2744
Expr2745
Y2H_bait Y2H010986
Y2H010987
Y2H010988
Y2H010991
Reference (5)
RemarkSequence connection from [Oegema K, Hyman AA], 02/06/010 krb
MethodGene