C02F5.1 | SMap | S_parent | Sequence | C02F5
|
| Chromosome | III |
|
Identity (5)
|
|
Gene_info
| Gene_class | knl
|
| |
Structured_description
| Provisional_description | knl-1 encodes a novel acidic protein with a coiled-coil region at its C-terminus; KNL-1 is an essential kinetochore component that is required for proper spindle elongation and chromosome separation, and in the kinetochore assembly pathway, plays a key role in linking the initiation of kinetochore formation with the construction of a functional microtubule-binding interface; in the assembly pathway, KNL-1 functions downstream of the DNA-proximal kinetochore components CeCENP-A/HCP-3 and CeCENP-B/HCP-4 and upstream of the outer kinetochore components HIM-10/Nuf2p, NDC-80/HEC1, CeBUB-1, HCP-1, and CeCLASP2/CLS-2; in expression studies in the one-cell embryo, KNL-1 localizes to kinetochores throughout mitosis. |
Paper_evidence
| WBPaper00004403
|
| | | | | | WBPaper00006142
|
| | | | | Person_evidence | WBPerson1843
|
| | | | | Curator_confirmed | WBPerson1843
|
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Concise_description | knl-1 encodes a novel acidic protein with a coiled-coil region at its C-terminus; KNL-1 is an essential kinetochore component that is required for proper spindle elongation and chromosome separation, and in the kinetochore assembly pathway, plays a key role in linking the initiation of kinetochore formation with the construction of a functional microtubule-binding interface; in the assembly pathway, KNL-1 functions downstream of the DNA-proximal kinetochore components CeCENP-A/HCP-3 and CeCENP-B/HCP-4 and upstream of the outer kinetochore components HIM-10/Nuf2p, NDC-80/HEC1, CeBUB-1, HCP-1, and CeCLASP2/CLS-2; in expression studies in the one-cell embryo, KNL-1 localizes to kinetochores throughout mitosis. |
|
Molecular_info
| Corresponding_CDS | C02F5.1
|
| | Corresponding_protein | WP:CE02450
|
| |
Corresponding_PCR_product
| smd_C02F5.1
|
| | | sjj_C02F5.1
|
| |
Corresponding_RNAi_reagent (7)
|
|
Experimental_info
|
RNAi_result
| Cenix:307-c1
|
| | | Cenix:312-f4
|
| | | JA:C02F5.1
|
| | | Simmer:C02F5.1
|
| | | TH:307C1
|
| |
WB_RNAi_result (7)
|
| |
Expr_pattern
| Expr2744
|
| | | Expr2745
|
| |
Y2H_bait
| Y2H010986
|
| | | Y2H010987
|
| | | Y2H010988
|
| | | Y2H010991
|
|
Reference (5)
|
| Remark | Sequence connection from [Oegema K, Hyman AA], 02/06/010 krb |
| Method | Gene
|