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Gene: C04F6.4 
| C04F6.4 | SMap | S_parent | Sequence | C04F6 | ||
|---|---|---|---|---|---|---|
| Chromosome | X | |||||
| Identity (5) | ||||||
| Gene_info | Gene_class | unc | ||||
| Reference_allele | e1217 | |||||
| Allele (7) | ||||||
| Phenotype (5) | ||||||
| Strain (5) | ||||||
| GO_term (8) | ||||||
| Structured_description | Provisional_description | The unc-78 gene encodes a homolog of actin-interacting protein 1 (AIP1) that regulates the ordered assembly of actin and cofilin in myofibrils. | Paper_evidence | WBPaper00004608 | ||
| WBPaper00004695 | ||||||
| Person_evidence | WBPerson567 | |||||
| Curator_confirmed | WBPerson567 | |||||
| Date_last_updated | 17 Jun 2004 00:00:00 | |||||
| In unc-78 mutants, striated actin filaments are disordered, and large actin aggregates abnormally appear. | ||||||
| UNC-60B, a muscle-specific actin depolymerizing factor (ADF)/cofilin isoform, is mislocalized to these aggregates; in wild-type animals UNC-60B is found in diffuse cytoplasm and along myofibrils. | ||||||
| unc-78 mutant phenotypes are similar in embryonic versus adult muscles. | ||||||
| Concise_description | The unc-78 gene encodes a homolog of actin-interacting protein 1 (AIP1) that regulates the ordered assembly of actin and cofilin in myofibrils. | |||||
| Molecular_info (5) | ||||||
| Experimental_info (5) | ||||||
| Reference (26) | ||||||
| Remark | Data extracted from Ono (2001) | |||||
| Method | Gene |
