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Gene: C04G2.4   

C04G2.4SMapS_parentSequenceC04G2
ChromosomeIV
Identity (5)
Gene_info Gene_classmsp
Phenotype[C.elegansII] NMK. Encodes MSP (16kD); msp-77 cluster. [Ward et al. (1988); BA]
GO_termGO:0005198 IEA Inferred_automatically
Structured_description Provisional_descriptionmsp-36 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family comprises of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSP is involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSP assembles into fibrous networks that drives movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. Paper_evidence WBPaper00001023
WBPaper00002143
WBPaper00004591
WBPaper00005670
Curator_confirmedWBPerson324
Date_last_updated22 Mar 2005 00:00:00
Concise_descriptionmsp-36 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family comprises of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSP is involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSP assembles into fibrous networks that drives movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes.
Molecular_info Corresponding_CDSC04G2.4
Corresponding_proteinWP:CE03853
Corresponding_PCR_product (44)
Corresponding_RNAi_reagent (52)
Experimental_info RNAi_result Cenix:242-d2
JA:C04G2.4
[cgc5655]:C04G2.4
WB_RNAi_result SA:yk386a12
JA:C04G2.4
JA:C09B9.6
JA:C34F11.4
JA:C34F11.6
JA:F09C12.7
JA:F26G1.7
JA:F32B6.6
JA:F36H12.7
JA:F58A6.8
JA:K05F1.7
JA:K07F5.1
JA:K07F5.2
JA:K07F5.3
JA:K08F4.8
JA:R05F9.13
JA:R05F9.3
JA:R05F9.8
JA:R13H9.2
JA:R13H9.4
JA:T13F2.10
JA:T13F2.11
JA:Y4C6A.c
JA:Y50E8.b
JA:ZK1248.17
JA:ZK1248.6
JA:ZK1251.6
JA:ZK354.1
JA:ZK354.11
JA:ZK354.4
JA:ZK354.5
JA:ZK546.3
JA:ZK546.6
JA:C33F10.9
[cgc5655]:C04G2.4
[cgc5655]:daf-2:R05F9.8
[cgc5655]:F32B6.6
[cgc5655]:R05F9.8
[cgc5655]:tph-1:R05F9.8
[cgc5655]:tub-1:R05F9.8
Simmer:ZK546.6:Repeat_a
Simmer:ZK546.6:Repeat_b
Simmer:ZK546.6:Screen
MV_SV:mv_C09B9.6
MV_SV:mv_C33F10.9
MV_SV:mv_C34F11.4
MV_SV:mv_C34F11.6
MV_SV:mv_F09C12.7
MV_SV:mv_F26G1.7
MV_SV:mv_F32B6.6
MV_SV:mv_F36H12.7
MV_SV:mv_K05F1.2
MV_SV:mv_K05F1.7
MV_SV:mv_R05F9.8
MV_SV:mv_Y59H11AM.d
MV_SV:mv_ZK1248.6
MV_SV:mv_ZK1251.6
MV_SV:mv_ZK354.4
MV_SV:mv_ZK546.6
Cenix:246-b8
Cenix:242-h2
Cenix:205-e12
Cenix:13-d1
Cenix:206-e1
Cenix:211-b4
Cenix:241-h1
Cenix:14-g4
Cenix:16-c9
Cenix:238-b12
Cenix:13-f11
Cenix:211-g4
Cenix:242-c6
Cenix:242-g7
Cenix:238-d8
JA:Y59E9_120.c
Expr_patternExpr3417
Reference (2)
MethodGene