RNAiDB Tree View

Gene: C05D2.1

C05D2.1	SMap	S_parent	Sequence	C05D2
	Chromosome	III
	Identity (5)
	Gene_info	Gene_class	daf
		Reference_allele	m63
		Allele (17)
		Phenotype	m63ts : constitutive dauer formation at 25x; reversible by shift to 15x; at all temperatures small and defective in intestinal endosytosis; Type E Egl. ES3 (L3 25x); ES2 (other stages). NA8 (e1364 m72amber etc; all alleles resemble m63).
			See also e1364, n957
			[C.elegansII] m63ts : constitutive dauer formation at 25C; reversible by shift to 15C; at all temperatures small and defective in intestinal endocytosis, similar to Sma-2; Type E Egl. Weak maternal rescue.ME0: males have crumpled spicules, fused and displaced rays.ES3 (L3 25C); ES2 (other stages). OA7: e1364,m72amb, sa183, sa185, m592ts (ts for Sma) etc; most alleles resemble m63. Cloned : encodes predicted 744 aa receptor Ser/Thr kinase, related to activin, TGF-beta receptor kinases. [Estevez et al. 1993; DR; JT; PB; PJ]
		Strain (9)
		GO_term (13)
		Structured_description	Provisional_description	daf-4 encodes a transmembrane serine/threonine kinase that is the sole C. elegans ortholog of the type II transforming growth factor-beta (TGF-b) receptors; DAF-4 activity is required for several biological processes, including entry into and exit from the dauer larval stage, body size determination, male tail patterning, egg laying, chemosensory neuron specification, and increased thermotolerance; in regulating dauer larval development, DAF-4 acts in parallel with the insulin signaling pathway and likely partners with the DAF-1 type I TGF-b receptor to receive a signal from the DAF-7 TGF-b ligand; in body size determination and male tail patterning, DAF-4 likely partners with the SMA-6 type I receptor and responds to signals from the DBL-1 ligand; DAF-4 expression begins in late embryogenesis and continues through larval and adult stages; consistent with its role in many developmental processes, DAF-4 localizes to the plasma membrane of several tissues including head and tail neurons, the pharynx, intestine, ventral nerve cord, tail hypodermis, and body wall muscle.	Paper_evidence (7)
					Person_evidence	WBPerson1843
					Curator_confirmed	WBPerson1843
					Date_last_updated	21 Sep 2004 00:00:00
				When expressed in COS cells, DAF-4 is able to bind human BMP2 and BMP4.
			Concise_description	daf-4 encodes a transmembrane serine/threonine kinase that is the sole C. elegans ortholog of the type II transforming growth factor-beta (TGF-b) receptors; DAF-4 activity is required for several biological processes, including entry into and exit from the dauer larval stage, body size determination, male tail patterning, egg laying, chemosensory neuron specification, and increased thermotolerance; in regulating dauer larval development, DAF-4 acts in parallel with the insulin signaling pathway and likely partners with the DAF-1 type I TGF-b receptor to receive a signal from the DAF-7 TGF-b ligand; in body size determination and male tail patterning, DAF-4 likely partners with the SMA-6 type I receptor and responds to signals from the DBL-1 ligand; DAF-4 expression begins in late embryogenesis and continues through larval and adult stages; consistent with its role in many developmental processes, DAF-4 localizes to the plasma membrane of several tissues including head and tail neurons, the pharynx, intestine, ventral nerve cord, tail hypodermis, and body wall muscle.
	Molecular_info (6)
	Experimental_info	RNAi_result	Cenix:301-e9
			JA:C05D2.1
			TH:301E9
		WB_RNAi_result	TH:301E9
			JA:C05D2.1
			Cenix:301-e9
		Expr_pattern (5)
		Interaction (31)
	Reference (238)
	Method	Gene