RNAiDB Tree View

Gene: C06G3.7

C06G3.7	SMap	S_parent	Sequence	SUPERLINK_RW4
	Chromosome	IV
	Identity (5)
	Gene_info	Gene_class	trxr
		GO_term (6)
		Structured_description	Provisional_description	C06G3.7 encodes an homolog of the mammalian thioredoxin reductase isozymes TR1 and TR2; like its mammalian homologs, C06G3.7 has a TGA-encoded C-terminal penultimate selenocysteine (Sec) residue; labelling of C. elegans with selenium-75 demonstrates that TR-Se is the major naturally occurring selenoprotein in C. elegans, and computational analysis indicates that it is probably the only selenoprotein encoded by the genome; the 3'-untranslated region of this gene contains a selenocysteine insertion sequence that is functional in mammalian cell culture; by phylogenetic profiling, C06G3.7 protein is predicted to be mitochondrial.	Paper_evidence	WBPaper00003571
						WBPaper00003621
						WBPaper00004424
						WBPaper00013278
					Person_evidence	WBPerson567
					Curator_confirmed	WBPerson567
					Date_last_updated	17 Jun 2004 00:00:00
				The C06G3.7 gene contains a a TGA selenocysteine codon at the same position as its mammalian homolog TTR, and a functional selenocysteine insertion sequence (SECIS) element.
				The TGA SeCys codon of C06G3.7 is currently treated as an actual stop to the CDS, and there may be other such cases in the genome as well.
				This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial.
				Proteins localized to a given organelle by experiments tend to share a characteristic phylogenetic distribution of their homologs, called a phylogenetic profile.
				For instance, mitochondrial proteins can be identified effectively by their phylogenetic profiles.
				By applying phylogenetic profile analysis to the C. elegans genome, Eisenberg and coworkers inferred that this gene, along with 2-4% of all the nuclear genes in C. elegans, encodes a mitochondrial protein.
				The large fraction of organism-specific and eukaryote-derived genes suggests that C. elegans mitochondria perform specialized roles absent from prokaryotic mitochondrial ancestors.
			Concise_description	C06G3.7 encodes an homolog of the mammalian thioredoxin reductase isozymes TR1 and TR2; like its mammalian homologs, C06G3.7 has a TGA-encoded C-terminal penultimate selenocysteine (Sec) residue; labelling of C. elegans with selenium-75 demonstrates that TR-Se is the major naturally occurring selenoprotein in C. elegans, and computational analysis indicates that it is probably the only selenoprotein encoded by the genome; the 3'-untranslated region of this gene contains a selenocysteine insertion sequence that is functional in mammalian cell culture; by phylogenetic profiling, C06G3.7 protein is predicted to be mitochondrial.
	Molecular_info (6)
	Experimental_info	RNAi_result	Cenix:39-b9
		WB_RNAi_result	Cenix:39-b9
	Method	Gene