RNAiDB Tree View

Gene: C06G4.2

C06G4.2	SMap	S_parent	Sequence	C06G4
	Chromosome	III
	Identity (5)
	Gene_info	Gene_class	clp
		Allele (5)
		GO_term	GO:0004197	IEA	Inferred_automatically
			GO:0006508	IEA	Inferred_automatically
			GO:0004198	IEA	Inferred_automatically
			GO:0005622	IEA	Inferred_automatically
		Structured_description	Provisional_description	clp-1 encodes a calpain homolog that has significant identity to mammalian calpains over its whole length and that contains motifs typical of calpains, including a thiol (cysteine) protease active site and a Ca[2+]-binding domain; CLP-1 is required, in parallel with TRA-3 but in series with ASP-3 and ASP-3, for degenerative (necrotic-like) cell death in neurons induced by mutations such as mec-4(d), deg-3(d), or gsa-1(gf).	Paper_evidence	WBPaper00005513
					Person_evidence	WBPerson567
					Curator_confirmed	WBPerson567
					Date_last_updated	17 Jun 2004 00:00:00
				clp-1(RNAi) suppresses neurodegeneration of mec-4(d), deg-3(d), or gsa-1(gf) mutants; suppression by clp-1(RNAi) is enhanced by also applying tra-3(RNAi), but not by asp-3(RNAi) or asp-4(RNAi).
				Moreover, neurodegeneration inflicted by cell-specific overexpression of asp-3 and asp-4 cannot be bypassed by a deficiency in either clp-1 or tra-3, implying that ASP-3 and ASP-4 are downstream of CLP-1 and TRA-3.
				clp-1 is expressed strongly in many types of cell and tissue, including muscle cells and neurons.
				One hypothesis to explain these data is that perturbation of intracellular concentrations of calcium may initiate neuronal degeneration by deregulating proteolysis.
			Concise_description	clp-1 encodes a calpain homolog that has significant identity to mammalian calpains over its whole length and that contains motifs typical of calpains, including a thiol (cysteine) protease active site and a Ca[2+]-binding domain; CLP-1 is required, in parallel with TRA-3 but in series with ASP-3 and ASP-3, for degenerative (necrotic-like) cell death in neurons induced by mutations such as mec-4(d), deg-3(d), or gsa-1(gf).
	Molecular_info (5)
	Experimental_info	RNAi_result (5)
		WB_RNAi_result (10)
		Expr_pattern	Expr6127
	Reference	WBPaper00005513
		WBPaper00006018
		WBPaper00005753
		WBPaper00026694
	Remark	Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.	CGC_data_submission
	Method	Gene