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Gene: C07H6.6 
| C07H6.6 | Evidence | CGC_data_submission | ||
|---|---|---|---|---|
| SMap | S_parent | Sequence | C07H6 | |
| Chromosome | III | |||
| Identity (5) | ||||
| Gene_info | Gene_class | clk | ||
| Reference_allele | mn159 | |||
| Allele (5) | ||||
| Phenotype (5) | ||||
| Strain (5) | ||||
| GO_term (6) | ||||
| Contained_in_operon | CEOP3444 | |||
| Structured_description | Provisional_description (9) | |||
| Concise_description | The clk-2 gene encodes an ortholog of the S. cerevisiae telomere length-regulating protein Tel2p that has been shown to bind a number of DNA structures in vitro, including single-, double- and four-stranded DNA; in C. elegans, CLK-2 activity is required for the DNA damage and S phase replication checkpoints, for embryonic development, and for normal biological rhythms and life span; a functional CLK-2::GFP fusion protein is detected exclusively in the cytoplasm of somatic tissues. | |||
| The clk-2 gene encodes an ortholog of the telomere length-regulating protein Tel2p from S. cerevisiae; clk-2 mutations extend lifespan, indicating that CLK-2 positively mediates some aspect of normal aging. | ||||
| Molecular_info (5) | ||||
| Experimental_info | RNAi_result | Cenix:305-c5 | ||
| TH:305C5 | ||||
| WB_RNAi_result | SA:yk346f3 | |||
| TH:305C5 | ||||
| Cenix:305-c5 | ||||
| Expr_pattern | Expr1675 | |||
| Expr1676 | ||||
| Expr1677 | ||||
| Interaction (9) | ||||
| Reference (65) | ||||
| Remark | Sequence connection from [Benard C, Hekimi S, Gartner A] | |||
| old_name rad-5 becomes new_name clk-2 from [Gartner A]. | ||||
| Method | Gene |
