RNAiDB Tree View

Gene: C08C3.3

C08C3.3	SMap	S_parent	Sequence	C08C3
	Chromosome	III
	Identity (5)
	Gene_info	Gene_class	mab
		Reference_allele	e1239
		Allele (8)
		Phenotype (5)
		Strain (11)
		GO_term (8)
		Structured_description	Provisional_description	mab-5 encodes a homeodomain protein related to the Antennapedia, Ultrabithorax, and abdominal-A family of homeodomain proteins; during postembryonic development, mab-5 is required cell autonomously for specification of posterior cell fates, including hypodermal and neuronal fates, programmed cell deaths, cell migrations, and fates of the male-specific copulatory muscles and sensory rays; in addition, activation of mab-5 in migrating cells is sufficient to alter their direction of migration; in regions of the body where mab-5 expression overlaps with that of lin-39, another C. elegans HOM-C gene, the two genes appear to either compensate for one another's activity or act combinatorially to promote cell fates distinct from those where either gene is expressed alone; a mab-5:lacZ reporter fusion is expressed in cells in the posterior body region from the mid-gastrulation stage of embryogenesis through larval and adult stages.	Paper_evidence	WBPaper00000913
						WBPaper00001492
						WBPaper00001767
						WBPaper00001815
					Curator_confirmed	WBPerson1843
					Date_last_updated	18 Aug 2005 00:00:00
			Concise_description	mab-5 encodes a homeodomain protein related to the Antennapedia, Ultrabithorax, and abdominal-A family of homeodomain proteins; during postembryonic development, mab-5 is required cell autonomously for specification of posterior cell fates, including hypodermal and neuronal fates, programmed cell deaths, cell migrations, and fates of the male-specific copulatory muscles and sensory rays; in addition, activation of mab-5 in migrating cells is sufficient to alter their direction of migration; in regions of the body where mab-5 expression overlaps with that of lin-39, another C. elegans HOM-C gene, the two genes appear to either compensate for one another's activity or act combinatorially to promote cell fates distinct from those where either gene is expressed alone; a mab-5:lacZ reporter fusion is expressed in cells in the posterior body region from the mid-gastrulation stage of embryogenesis through larval and adult stages.
	Molecular_info (6)
	Experimental_info (5)
	Reference (330)
	Remark	[e1751 is in fact a tandem duplication of 100 kb that includes mab-5, and therefore has mab-5(gf) properties [JAH][021015 ck1]
	Method	Gene