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Gene: C08F1.3   

C08F1.3SMapS_parentSequenceC08F1
ChromosomeII
Identity (5)
Gene_info Structured_description Provisional_description This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function.Paper_evidenceWBPaper00012854
Person_evidenceWBPerson567
Curator_confirmedWBPerson567
Date_last_updated17 Jun 2004 00:00:00
The F-box motif consists of roughly 50 amino acids.
There are at least 11 F-box genes encoded by the genome of budding yeast, 22 in Drosophila, and 38 in human beings; but a striking 326 F-box genes are predicted to exist in C. elegans, comprising 1.6% of the protein-coding genome.
This disproportionate number of F-box genes is paralleled by the number of Skp-1 homologs (which are potential F-box ligands) encoded in these genomes: while there are 2, 7, and 1 Skp-1 related genes predicted in the genomes of Dictyostelium discoideum, Drosophila, and Homo sapiens, there are 17 Skp-1 homologs in C. elegans.
F-box proteins were first characterized as components of SCF ubiquitin-ligase complexes (named after their main components, Skp-1, Cullin, and an F-box protein), in which they bind substrates for ubiquitination (and, thus, subsequent proteolysis); in SCF complexes, the F-box motif links its protein to other SCF components by binding Skp-1 protein.
However, F-box proteins are by no means confined solely to SCF complexes.
For instance, yeast Skp-1 can bind non-SCF F-box proteins to perform cellular functions completely distinct from protein degradation, such as kinetochore function (binding the F-box protein Ctf13p) or SNARE recycling (by binding the F-box protein Rcy1p), as well as yet other F-box proteins of unknown function (Yjl149 and Yml088).
Concise_descriptionThis gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function.
Molecular_info Corresponding_CDSC08F1.3
Corresponding_proteinWP:CE08018
Corresponding_PCR_product smd_C08F1.3
sjj_C08F1.3
Corresponding_RNAi_reagent Cenix:106-h6
sjj_C08F1.3
mv_C08F1.3
Experimental_info RNAi_result Cenix:106-h6
JA:C08F1.3
WB_RNAi_result SA:yk393f1
JA:C08F1.3
MV_SV:mv_C08F1.3
Cenix:106-h6
MethodGene