C08F1.3 | SMap | S_parent | Sequence | C08F1
|
| Chromosome | II |
|
Identity (5)
|
| Gene_info |
Structured_description
|
Provisional_description
| This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. | Paper_evidence | WBPaper00012854
|
| | | | | Person_evidence | WBPerson567
|
| | | | | Curator_confirmed | WBPerson567
|
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | | The F-box motif consists of roughly 50 amino acids. |
| | | | There are at least 11 F-box genes encoded by the genome of budding yeast, 22 in Drosophila, and 38 in human beings; but a striking 326 F-box genes are predicted to exist in C. elegans, comprising 1.6% of the protein-coding genome. |
| | | | This disproportionate number of F-box genes is paralleled by the number of Skp-1 homologs (which are potential F-box ligands) encoded in these genomes: while there are 2, 7, and 1 Skp-1 related genes predicted in the genomes of Dictyostelium discoideum, Drosophila, and Homo sapiens, there are 17 Skp-1 homologs in C. elegans. |
| | | | F-box proteins were first characterized as components of SCF ubiquitin-ligase complexes (named after their main components, Skp-1, Cullin, and an F-box protein), in which they bind substrates for ubiquitination (and, thus, subsequent proteolysis); in SCF complexes, the F-box motif links its protein to other SCF components by binding Skp-1 protein. |
| | | | However, F-box proteins are by no means confined solely to SCF complexes. |
| | | | For instance, yeast Skp-1 can bind non-SCF F-box proteins to perform cellular functions completely distinct from protein degradation, such as kinetochore function (binding the F-box protein Ctf13p) or SNARE recycling (by binding the F-box protein Rcy1p), as well as yet other F-box proteins of unknown function (Yjl149 and Yml088). |
| | | Concise_description | This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function. |
|
Molecular_info
| Corresponding_CDS | C08F1.3
|
| | Corresponding_protein | WP:CE08018
|
| |
Corresponding_PCR_product
| smd_C08F1.3
|
| | | sjj_C08F1.3
|
| |
Corresponding_RNAi_reagent (3)
|
|
Experimental_info
|
RNAi_result
| Cenix:106-h6
|
| | | JA:C08F1.3
|
| |
WB_RNAi_result
| SA:yk393f1
|
| | | JA:C08F1.3
|
| | | MV_SV:mv_C08F1.3
|
| | | Cenix:106-h6
|
| Method | Gene
|