Gene: C09D8.1
C09D8.1 | SMap | S_parent | Sequence | SUPERLINK_CB_II | ||
---|---|---|---|---|---|---|
Chromosome | II | |||||
Identity (5) | ||||||
Gene_info | Gene_class | ptp | ||||
Allele (10) | ||||||
Phenotype | [Chisholm AD] op147 mutation is a Tc1 insertion in the first phosphatase domain of PTP-1. op147 mutants display variable low penetrance defects in epidermal morphogenesis; about 5% embryonic lethals at 20. op147 is slightly ts. | |||||
[C.elegansII] NMK. Encodes predicted tyrosine phosphatase. [CR] | ||||||
Strain | CZ540 | |||||
RB633 | ||||||
GO_term | GO:0007369 | IMP | Paper_evidence | WBPaper00005259 | ||
Curator_confirmed | WBPerson324 | |||||
GO:0008544 | IMP | Paper_evidence | WBPaper00005259 | |||
Curator_confirmed | WBPerson324 | |||||
GO:0007416 | TAS | Paper_evidence | WBPaper00018909 | |||
Curator_confirmed | WBPerson324 | |||||
GO:0006470 | ISS | Paper_evidence | WBPaper00005259 | |||
Curator_confirmed | WBPerson324 | |||||
IEA | Inferred_automatically | |||||
GO:0005912 | IDA | Paper_evidence | WBPaper00005259 | |||
Curator_confirmed | WBPerson324 | |||||
GO:0005001 | ISS | Paper_evidence | WBPaper00005259 | |||
Curator_confirmed | WBPerson324 | |||||
GO:0004721 | IEA | Inferred_automatically | ||||
GO:0004725 | IEA | Inferred_automatically | ||||
Structured_description | Provisional_description | ptp-3 encodes a receptor-like tyrosine phosphatase orthologous to the LAR (Leukocyte Common Antigen Related, OMIM:179590) subfamily of receptor-like tyrosine phosphatases that contain extracellular immunoglobulin-like and fibronectin type III domains and have been implicated in linking cell adhesion to intracellular phosphotyrosine levels; PTP-3 plays a role in gastrulation and epidermal development and functions partly redundantly with the VAB-1 Eph receptor and ephrins VAB-2 and EFN-4 to regulate embryonic morphogenesis; PTP-3 is expressed in many tissues during early embryogenesis, but expression later becomes localized to neuronal processes and epithelial adherens junctions. | Paper_evidence | WBPaper00005259 | ||
WBPaper00005631 | ||||||
Person_evidence | WBPerson1843 | |||||
Curator_confirmed | WBPerson1843 | |||||
Date_last_updated | 17 Jun 2004 00:00:00 | |||||
Concise_description | ptp-3 encodes a receptor-like tyrosine phosphatase orthologous to the LAR (Leukocyte Common Antigen Related, OMIM:179590) subfamily of receptor-like tyrosine phosphatases that contain extracellular immunoglobulin-like and fibronectin type III domains and have been implicated in linking cell adhesion to intracellular phosphotyrosine levels; PTP-3 plays a role in gastrulation and epidermal development and functions partly redundantly with the VAB-1 Eph receptor and ephrins VAB-2 and EFN-4 to regulate embryonic morphogenesis; PTP-3 is expressed in many tissues during early embryogenesis, but expression later becomes localized to neuronal processes and epithelial adherens junctions. | |||||
Molecular_info | Corresponding_CDS | C09D8.1a | ||||
C09D8.1b | ||||||
C09D8.1c | ||||||
Corresponding_CDS_history | C09D8.1:wp72 | |||||
Corresponding_protein | WP:CE30244 | |||||
WP:CE30245 | ||||||
WP:CE32793 | ||||||
Corresponding_PCR_product | smd_C09D8.1 | |||||
smd_C09D8.2 | ||||||
sjj_C09D8.2 | ||||||
sjj_C09D8.1 | ||||||
Corresponding_RNAi_reagent (5) | ||||||
Other_sequence | AF316539 | |||||
AF316540 | ||||||
Experimental_info (5) | ||||||
Reference (14) | ||||||
Remark | Worm ortholog of LAR-family receptor tyrosine phosphatases Worm ortholog of LAR-family receptor tyrosine phosphatase. Chisholm AD | |||||
This gene was originally called ptp-1 (and ypp-1 before that), but ptp-1 is now a separate and different gene [020809 krb] | ||||||
Method | Gene |