Gene: C09D8.1
C09D8.1 | SMap | S_parent | Sequence | SUPERLINK_CB_II | ||
---|---|---|---|---|---|---|
Chromosome | II | |||||
Identity (5) | ||||||
Gene_info | Gene_class | ptp | ||||
Allele (10) | ||||||
Phenotype | [Chisholm AD] op147 mutation is a Tc1 insertion in the first phosphatase domain of PTP-1. op147 mutants display variable low penetrance defects in epidermal morphogenesis; about 5% embryonic lethals at 20. op147 is slightly ts. | |||||
[C.elegansII] NMK. Encodes predicted tyrosine phosphatase. [CR] | ||||||
Strain | CZ540 | |||||
RB633 | ||||||
GO_term (8) | ||||||
Structured_description | Provisional_description | ptp-3 encodes a receptor-like tyrosine phosphatase orthologous to the LAR (Leukocyte Common Antigen Related, OMIM:179590) subfamily of receptor-like tyrosine phosphatases that contain extracellular immunoglobulin-like and fibronectin type III domains and have been implicated in linking cell adhesion to intracellular phosphotyrosine levels; PTP-3 plays a role in gastrulation and epidermal development and functions partly redundantly with the VAB-1 Eph receptor and ephrins VAB-2 and EFN-4 to regulate embryonic morphogenesis; PTP-3 is expressed in many tissues during early embryogenesis, but expression later becomes localized to neuronal processes and epithelial adherens junctions. | Paper_evidence | WBPaper00005259 | ||
WBPaper00005631 | ||||||
Person_evidence | WBPerson1843 | |||||
Curator_confirmed | WBPerson1843 | |||||
Date_last_updated | 17 Jun 2004 00:00:00 | |||||
Concise_description | ptp-3 encodes a receptor-like tyrosine phosphatase orthologous to the LAR (Leukocyte Common Antigen Related, OMIM:179590) subfamily of receptor-like tyrosine phosphatases that contain extracellular immunoglobulin-like and fibronectin type III domains and have been implicated in linking cell adhesion to intracellular phosphotyrosine levels; PTP-3 plays a role in gastrulation and epidermal development and functions partly redundantly with the VAB-1 Eph receptor and ephrins VAB-2 and EFN-4 to regulate embryonic morphogenesis; PTP-3 is expressed in many tissues during early embryogenesis, but expression later becomes localized to neuronal processes and epithelial adherens junctions. | |||||
Molecular_info (6) | ||||||
Experimental_info | RNAi_result | Cenix:201-c1 | ||||
JA:C09D8.1 | ||||||
JA:C09D8.2 | ||||||
WB_RNAi_result (5) | ||||||
Expr_pattern | Expr1887 | |||||
Expr1940 | ||||||
Expr6407 | ||||||
Y2H_bait | Y2H002652 | |||||
Interaction | WBInteraction0001685 | |||||
WBInteraction0001687 | ||||||
WBInteraction0001688 | ||||||
WBInteraction0001689 | ||||||
WBInteraction0001937 | ||||||
WBInteraction0001942 | ||||||
WBInteraction0001943 | ||||||
WBInteraction0002658 | ||||||
WBInteraction0002660 | ||||||
WBInteraction0002661 | ||||||
WBInteraction0002662 | ||||||
WBInteraction0002818 | ||||||
WBInteraction0002819 | ||||||
WBInteraction0002820 | ||||||
Reference (14) | ||||||
Remark (2) | ||||||
Method | Gene |