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Gene: C09H6.2   

C09H6.2SMapS_parentSequenceC09H6
ChromosomeI
Identity (5)
Gene_info Gene_classlin
Reference_allelee1439
Allele e1438 Inferred_automatically From strain object: BW538
From strain object: BW589
From strain object: BW635
e1439 Inferred_automatically From strain object: CB1439
From strain object: MT2351
From strain object: RW1482
n299
n1299 Inferred_automaticallyFrom strain object: MT2981
n1326 Inferred_automaticallyFrom strain object: MT2981
n1386 Inferred_automaticallyFrom strain object: MT3228
n1387 Inferred_automaticallyFrom strain object: MT3229
n1390 Inferred_automatically From strain object: MT3232
From strain object: VT592
n1402 Inferred_automaticallyFrom strain object: MT3252
n1508
n1511 Inferred_automaticallyFrom strain object: MT3632
n1638
n1759 Inferred_automaticallyFrom strain object: MT4006
n1853 Inferred_automaticallyFrom strain object: MT4351
sy217
uCE1-957
uCE1-958
Phenotype e1439 : adult hermaphrodite vulvaless (penetrance 95%) HME2; adult male wildtype ME3. Similar phenotype in e1439/Df. NA3 (e1438 n299).
See also e1438, e1439, n299, n1299, n1329
[C.elegansII] e1439 : adult hermaphrodite vulvaless (penetrance 95%) HME2; adult male wildtype ME3. Similar phenotype in e1439/Df. OA>5; e1438, n299, n1299, n1329, n1638amb, etc.C loned: encodes predicted 407aa novel protein;antibody staining indicates ubiquitous,cytoplasmic. [Kim and Horvitz 1990; MT; SD]
Strain (15)
GO_term (13)
Structured_description Provisional_descriptionThe lin-10 gene encodes a PDZ and PTB domain-containing protein that is homologous to mammalian Munc interacting proteins (Mint1, OMIM:602414) and is required for polarized protein localization; LIN-10 is required for proper localization of the LET-23 EGF receptor to the basolateral membrane of the vulval precursor cells and for proper postsynaptic localization of GLR-1, an AMPA-type glutamate receptor in interneurons; LIN-10 is detected in the cytoplasm, membrane, and at particularly high levels in the Golgi. Paper_evidence WBPaper00003214
WBPaper00003566
WBPaper00005047
WBPaper00005666
Person_evidenceWBPerson1843
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
Concise_descriptionThe lin-10 gene encodes a PDZ and PTB domain-containing protein that is homologous to mammalian Munc interacting proteins (Mint1, OMIM:602414) and is required for polarized protein localization; LIN-10 is required for proper localization of the LET-23 EGF receptor to the basolateral membrane of the vulval precursor cells and for proper postsynaptic localization of GLR-1, an AMPA-type glutamate receptor in interneurons; LIN-10 is detected in the cytoplasm, membrane, and at particularly high levels in the Golgi.
Molecular_info (7)
Experimental_info RNAi_result Cenix:71-e2
JA:C09H6.2
WB_RNAi_result SA:yk297c2
JA:C09H6.2
Cenix:71-e2
Expr_pattern Expr1282
Expr1385
Expr5703
Expr5704
Interaction (12)
Reference (128)
Remarklin-10 is NOT T01G9.2 [jah 8/99]
MethodGene