RNAiDB Tree View

Gene: C09H6.2

C09H6.2	SMap	S_parent	Sequence	C09H6
	Chromosome	I
	Identity (5)
	Gene_info	Gene_class	lin
		Reference_allele	e1439
		Allele (17)
		Phenotype	e1439 : adult hermaphrodite vulvaless (penetrance 95%) HME2; adult male wildtype ME3. Similar phenotype in e1439/Df. NA3 (e1438 n299).
			See also e1438, e1439, n299, n1299, n1329
			[C.elegansII] e1439 : adult hermaphrodite vulvaless (penetrance 95%) HME2; adult male wildtype ME3. Similar phenotype in e1439/Df. OA>5; e1438, n299, n1299, n1329, n1638amb, etc.C loned: encodes predicted 407aa novel protein;antibody staining indicates ubiquitous,cytoplasmic. [Kim and Horvitz 1990; MT; SD]
		Strain (15)
		GO_term (13)
		Structured_description	Provisional_description	The lin-10 gene encodes a PDZ and PTB domain-containing protein that is homologous to mammalian Munc interacting proteins (Mint1, OMIM:602414) and is required for polarized protein localization; LIN-10 is required for proper localization of the LET-23 EGF receptor to the basolateral membrane of the vulval precursor cells and for proper postsynaptic localization of GLR-1, an AMPA-type glutamate receptor in interneurons; LIN-10 is detected in the cytoplasm, membrane, and at particularly high levels in the Golgi.	Paper_evidence	WBPaper00003214
						WBPaper00003566
						WBPaper00005047
						WBPaper00005666
					Person_evidence	WBPerson1843
					Curator_confirmed	WBPerson1843
					Date_last_updated	17 Jun 2004 00:00:00
			Concise_description	The lin-10 gene encodes a PDZ and PTB domain-containing protein that is homologous to mammalian Munc interacting proteins (Mint1, OMIM:602414) and is required for polarized protein localization; LIN-10 is required for proper localization of the LET-23 EGF receptor to the basolateral membrane of the vulval precursor cells and for proper postsynaptic localization of GLR-1, an AMPA-type glutamate receptor in interneurons; LIN-10 is detected in the cytoplasm, membrane, and at particularly high levels in the Golgi.
	Molecular_info (7)
	Experimental_info	RNAi_result	Cenix:71-e2
			JA:C09H6.2
		WB_RNAi_result	SA:yk297c2
			JA:C09H6.2
			Cenix:71-e2
		Expr_pattern (4)
		Interaction (12)
	Reference (128)
	Remark	lin-10 is NOT T01G9.2 [jah 8/99]
	Method	Gene