Go to RNAiDB Home Adult Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie
 

Gene: C12C8.3   

C12C8.3EvidenceCGC_data_submission
SMapS_parentSequenceC12C8
ChromosomeI
Identity (5)
Gene_info Gene_classlin
Allele (6)
Phenotype [C.elegansII] ma104 : heterochronic defect in L4/A switch. [VT]
[Fitch DHA] lep for LEPtoderan tail bx37 male tail tip is pointy and protrudes beyond the posterior edge of the fan. No hermaphrodite phenotype.
[C.elegansII] bx37sd : male tail tip is pointy and protrudes beyond the posterior edge of the fan, 100%penetrant. No hermaphrodite phenotype. OA1: bx42sd (92% penetrant). [DF]
Strain CT8
MT7897
GO_term (12)
Structured_description Provisional_description The lin-41 gene encodes a novel RBCC (Ring finger-B box-Coiled coil) protein that is a member of the NHL (NCL-1, HT2A, and LIN-41) family of proteins and is required for the proper temporal control of specific postembryonic cell fates; lin-41 translation is negatively regulated during L4 and adult stages by let-7, a small temporally regulated RNA (stRNA) that is complementary to two sites in the lin-41 3'UTR; LIN-41 is a widely expressed cytoplasmic protein and negatively regulates post-transcriptional expression of LIN-29, a transcription factor required for adult cell fates. Paper_evidence WBPaper00005067
WBPaper00011140
WBPaper00012866
WBPaper00023473
Person_evidence WBPerson178
WBPerson1843
Curator_confirmedWBPerson1843
Date_last_updated08 Aug 2005 00:00:00
The leptoderan alleles lin-41(bx37) and lin-41(bx42) specifically affect development of the male tail; they cause no defects in the development of alae or in hermaphrodites.
These two alleles were originally considered to define a new gene (lep-1); they were identified in a screen for mutants with atavistic male tail morphological defects.
Concise_descriptionThe lin-41 gene encodes a novel RBCC (Ring finger-B box-Coiled coil) protein that is a member of the NHL (NCL-1, HT2A, and LIN-41) family of proteins and is required for the proper temporal control of specific postembryonic cell fates; lin-41 translation is negatively regulated during L4 and adult stages by let-7, a small temporally regulated RNA (stRNA) that is complementary to two sites in the lin-41 3'UTR; LIN-41 is a widely expressed cytoplasmic protein and negatively regulates post-transcriptional expression of LIN-29, a transcription factor required for adult cell fates.
Molecular_info (8)
Experimental_info RNAi_result Cenix:137-e7
JA:C12C8.3
Simmer:C12C8.3:Screen_A
Simmer:C12C8.3:Screen_B
WB_RNAi_result (5)
Interaction (50)
Reference (68)
Remarkinx-20 and lep-1 has been merged in WS89 and unmerged in WS104 due to SNP mapping evidence. Unmerging also unlinks its other_name opu-20 which is an other_name of inx-20Person_evidenceWBPerson178
MethodGene