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Gene: C12C8.3 
| C12C8.3 | Evidence | CGC_data_submission | ||||
|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C12C8 | |||
| Chromosome | I | |||||
| Identity (5) | ||||||
| Gene_info | Gene_class | lin | ||||
| Allele (6) | ||||||
| Phenotype | [C.elegansII] ma104 : heterochronic defect in L4/A switch. [VT] | |||||
| [Fitch DHA] lep for LEPtoderan tail bx37 male tail tip is pointy and protrudes beyond the posterior edge of the fan. No hermaphrodite phenotype. | ||||||
| [C.elegansII] bx37sd : male tail tip is pointy and protrudes beyond the posterior edge of the fan, 100%penetrant. No hermaphrodite phenotype. OA1: bx42sd (92% penetrant). [DF] | ||||||
| Strain | CT8 | |||||
| MT7897 | ||||||
| GO_term (12) | ||||||
| Structured_description | Provisional_description | The lin-41 gene encodes a novel RBCC (Ring finger-B box-Coiled coil) protein that is a member of the NHL (NCL-1, HT2A, and LIN-41) family of proteins and is required for the proper temporal control of specific postembryonic cell fates; lin-41 translation is negatively regulated during L4 and adult stages by let-7, a small temporally regulated RNA (stRNA) that is complementary to two sites in the lin-41 3'UTR; LIN-41 is a widely expressed cytoplasmic protein and negatively regulates post-transcriptional expression of LIN-29, a transcription factor required for adult cell fates. | Paper_evidence | WBPaper00005067 | ||
| WBPaper00011140 | ||||||
| WBPaper00012866 | ||||||
| WBPaper00023473 | ||||||
| Person_evidence | WBPerson178 | |||||
| WBPerson1843 | ||||||
| Curator_confirmed | WBPerson1843 | |||||
| Date_last_updated | 08 Aug 2005 00:00:00 | |||||
| The leptoderan alleles lin-41(bx37) and lin-41(bx42) specifically affect development of the male tail; they cause no defects in the development of alae or in hermaphrodites. | ||||||
| These two alleles were originally considered to define a new gene (lep-1); they were identified in a screen for mutants with atavistic male tail morphological defects. | ||||||
| Concise_description | The lin-41 gene encodes a novel RBCC (Ring finger-B box-Coiled coil) protein that is a member of the NHL (NCL-1, HT2A, and LIN-41) family of proteins and is required for the proper temporal control of specific postembryonic cell fates; lin-41 translation is negatively regulated during L4 and adult stages by let-7, a small temporally regulated RNA (stRNA) that is complementary to two sites in the lin-41 3'UTR; LIN-41 is a widely expressed cytoplasmic protein and negatively regulates post-transcriptional expression of LIN-29, a transcription factor required for adult cell fates. | |||||
| Molecular_info (8) | ||||||
| Experimental_info | RNAi_result | Cenix:137-e7 | ||||
| JA:C12C8.3 | ||||||
| Simmer:C12C8.3:Screen_A | ||||||
| Simmer:C12C8.3:Screen_B | ||||||
| WB_RNAi_result (5) | ||||||
| Interaction | WBInteraction0001018 | |||||
| WBInteraction0001056 | ||||||
| WBInteraction0001057 | ||||||
| WBInteraction0001392 | ||||||
| WBInteraction0001408 | ||||||
| WBInteraction0001447 | ||||||
| WBInteraction0001461 | ||||||
| WBInteraction0001576 | ||||||
| WBInteraction0001578 | ||||||
| WBInteraction0001641 | ||||||
| WBInteraction0002109 | ||||||
| WBInteraction0002112 | ||||||
| WBInteraction0002113 | ||||||
| WBInteraction0002118 | ||||||
| WBInteraction0002119 | ||||||
| WBInteraction0002140 | ||||||
| WBInteraction0002216 | ||||||
| WBInteraction0002217 | ||||||
| WBInteraction0002218 | ||||||
| WBInteraction0002556 | ||||||
| WBInteraction0002617 | ||||||
| WBInteraction0002772 | ||||||
| WBInteraction0002919 | ||||||
| WBInteraction0002920 | ||||||
| WBInteraction0002977 | ||||||
| WBInteraction0003295 | ||||||
| WBInteraction0003311 | ||||||
| WBInteraction0003314 | ||||||
| WBInteraction0003328 | ||||||
| WBInteraction0003337 | ||||||
| WBInteraction0003364 | ||||||
| WBInteraction0003448 | ||||||
| WBInteraction0003451 | ||||||
| WBInteraction0003469 | ||||||
| WBInteraction0003628 | ||||||
| WBInteraction0003629 | ||||||
| WBInteraction0003731 | ||||||
| WBInteraction0003737 | ||||||
| WBInteraction0003748 | ||||||
| WBInteraction0003756 | ||||||
| WBInteraction0003779 | ||||||
| WBInteraction0003801 | ||||||
| WBInteraction0003826 | ||||||
| WBInteraction0003977 | ||||||
| WBInteraction0003999 | ||||||
| WBInteraction0004000 | ||||||
| WBInteraction0004065 | ||||||
| WBInteraction0004074 | ||||||
| WBInteraction0004076 | ||||||
| WBInteraction0004109 | ||||||
| Reference (68) | ||||||
| Remark | inx-20 and lep-1 has been merged in WS89 and unmerged in WS104 due to SNP mapping evidence. Unmerging also unlinks its other_name opu-20 which is an other_name of inx-20 | Person_evidence | WBPerson178 | |||
| Method | Gene |
