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Gene: C12C8.3 
| C12C8.3 | Evidence | CGC_data_submission | ||||
|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C12C8 | |||
| Chromosome | I | |||||
| Identity (5) | ||||||
| Gene_info | Gene_class | lin | ||||
| Allele (6) | ||||||
| Phenotype | [C.elegansII] ma104 : heterochronic defect in L4/A switch. [VT] | |||||
| [Fitch DHA] lep for LEPtoderan tail bx37 male tail tip is pointy and protrudes beyond the posterior edge of the fan. No hermaphrodite phenotype. | ||||||
| [C.elegansII] bx37sd : male tail tip is pointy and protrudes beyond the posterior edge of the fan, 100%penetrant. No hermaphrodite phenotype. OA1: bx42sd (92% penetrant). [DF] | ||||||
| Strain | CT8 | |||||
| MT7897 | ||||||
| GO_term (12) | ||||||
| Structured_description | Provisional_description | The lin-41 gene encodes a novel RBCC (Ring finger-B box-Coiled coil) protein that is a member of the NHL (NCL-1, HT2A, and LIN-41) family of proteins and is required for the proper temporal control of specific postembryonic cell fates; lin-41 translation is negatively regulated during L4 and adult stages by let-7, a small temporally regulated RNA (stRNA) that is complementary to two sites in the lin-41 3'UTR; LIN-41 is a widely expressed cytoplasmic protein and negatively regulates post-transcriptional expression of LIN-29, a transcription factor required for adult cell fates. | Paper_evidence | WBPaper00005067 | ||
| WBPaper00011140 | ||||||
| WBPaper00012866 | ||||||
| WBPaper00023473 | ||||||
| Person_evidence | WBPerson178 | |||||
| WBPerson1843 | ||||||
| Curator_confirmed | WBPerson1843 | |||||
| Date_last_updated | 08 Aug 2005 00:00:00 | |||||
| The leptoderan alleles lin-41(bx37) and lin-41(bx42) specifically affect development of the male tail; they cause no defects in the development of alae or in hermaphrodites. | ||||||
| These two alleles were originally considered to define a new gene (lep-1); they were identified in a screen for mutants with atavistic male tail morphological defects. | ||||||
| Concise_description | The lin-41 gene encodes a novel RBCC (Ring finger-B box-Coiled coil) protein that is a member of the NHL (NCL-1, HT2A, and LIN-41) family of proteins and is required for the proper temporal control of specific postembryonic cell fates; lin-41 translation is negatively regulated during L4 and adult stages by let-7, a small temporally regulated RNA (stRNA) that is complementary to two sites in the lin-41 3'UTR; LIN-41 is a widely expressed cytoplasmic protein and negatively regulates post-transcriptional expression of LIN-29, a transcription factor required for adult cell fates. | |||||
| Molecular_info (8) | ||||||
| Experimental_info | RNAi_result | Cenix:137-e7 | ||||
| JA:C12C8.3 | ||||||
| Simmer:C12C8.3:Screen_A | ||||||
| Simmer:C12C8.3:Screen_B | ||||||
| WB_RNAi_result (5) | ||||||
| Interaction (50) | ||||||
| Reference | WBPaper00003929 | |||||
| WBPaper00004111 | ||||||
| WBPaper00011140 | ||||||
| WBPaper00023185 | ||||||
| WBPaper00002970 | ||||||
| WBPaper00015363 | ||||||
| WBPaper00003707 | ||||||
| WBPaper00004231 | ||||||
| WBPaper00004399 | ||||||
| WBPaper00004402 | ||||||
| WBPaper00005192 | ||||||
| WBPaper00005601 | ||||||
| WBPaper00005908 | ||||||
| WBPaper00005909 | ||||||
| WBPaper00005947 | ||||||
| WBPaper00005971 | ||||||
| WBPaper00006101 | ||||||
| WBPaper00006376 | ||||||
| WBPaper00010447 | ||||||
| WBPaper00010549 | ||||||
| WBPaper00010550 | ||||||
| WBPaper00010728 | ||||||
| WBPaper00010863 | ||||||
| WBPaper00013416 | ||||||
| WBPaper00017895 | ||||||
| WBPaper00017960 | ||||||
| WBPaper00018442 | ||||||
| WBPaper00018444 | ||||||
| WBPaper00018445 | ||||||
| WBPaper00018447 | ||||||
| WBPaper00018454 | ||||||
| WBPaper00019003 | ||||||
| WBPaper00019532 | ||||||
| WBPaper00020927 | ||||||
| WBPaper00023473 | ||||||
| WBPaper00006075 | ||||||
| WBPaper00024828 | ||||||
| WBPaper00006345 | ||||||
| WBPaper00019005 | ||||||
| WBPaper00006387 | ||||||
| WBPaper00006019 | ||||||
| WBPaper00024225 | ||||||
| WBPaper00024529 | ||||||
| WBPaper00005201 | ||||||
| WBPaper00025125 | ||||||
| WBPaper00025627 | ||||||
| WBPaper00025651 | ||||||
| WBPaper00025709 | ||||||
| WBPaper00025970 | ||||||
| WBPaper00026386 | ||||||
| WBPaper00026492 | ||||||
| WBPaper00026508 | ||||||
| WBPaper00004116 | ||||||
| WBPaper00015631 | ||||||
| WBPaper00003418 | ||||||
| WBPaper00014318 | ||||||
| WBPaper00004389 | ||||||
| WBPaper00002950 | ||||||
| WBPaper00003780 | ||||||
| WBPaper00004144 | ||||||
| WBPaper00011181 | ||||||
| WBPaper00017745 | ||||||
| WBPaper00022146 | ||||||
| WBPaper00022278 | ||||||
| WBPaper00022838 | ||||||
| WBPaper00023811 | ||||||
| WBPaper00026477 | ||||||
| WBPaper00026761 | ||||||
| Remark | inx-20 and lep-1 has been merged in WS89 and unmerged in WS104 due to SNP mapping evidence. Unmerging also unlinks its other_name opu-20 which is an other_name of inx-20 | Person_evidence | WBPerson178 | |||
| Method | Gene |
