C12C8.3 | Evidence | CGC_data_submission |
| SMap | S_parent | Sequence | C12C8
|
| Chromosome | I |
|
Identity (5)
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Gene_info
| Gene_class | lin
|
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Allele (6)
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Phenotype
| [C.elegansII] ma104 : heterochronic defect in L4/A switch. [VT] |
| | | [Fitch DHA] lep for LEPtoderan tail bx37 male tail tip is pointy and protrudes beyond the posterior edge of the fan. No hermaphrodite phenotype. |
| | | [C.elegansII] bx37sd : male tail tip is pointy and protrudes beyond the posterior edge of the fan, 100%penetrant. No hermaphrodite phenotype. OA1: bx42sd (92% penetrant). [DF] |
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Strain
| CT8
|
| | | MT7897
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GO_term (12)
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Structured_description
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Provisional_description
| The lin-41 gene encodes a novel RBCC (Ring finger-B box-Coiled coil) protein that is a member of the NHL (NCL-1, HT2A, and LIN-41) family of proteins and is required for the proper temporal control of specific postembryonic cell fates; lin-41 translation is negatively regulated during L4 and adult stages by let-7, a small temporally regulated RNA (stRNA) that is complementary to two sites in the lin-41 3'UTR; LIN-41 is a widely expressed cytoplasmic protein and negatively regulates post-transcriptional expression of LIN-29, a transcription factor required for adult cell fates. |
Paper_evidence
| WBPaper00005067
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| | | | | | WBPaper00011140
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| | | | | | WBPaper00012866
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| | | | | | WBPaper00023473
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Person_evidence
| WBPerson178
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| | | | | | WBPerson1843
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| | | | | Curator_confirmed | WBPerson1843
|
| | | | | Date_last_updated | 08 Aug 2005 00:00:00 |
| | | | The leptoderan alleles lin-41(bx37) and lin-41(bx42) specifically affect development of the male tail; they cause no defects in the development of alae or in hermaphrodites. |
| | | | These two alleles were originally considered to define a new gene (lep-1); they were identified in a screen for mutants with atavistic male tail morphological defects. |
| | | Concise_description | The lin-41 gene encodes a novel RBCC (Ring finger-B box-Coiled coil) protein that is a member of the NHL (NCL-1, HT2A, and LIN-41) family of proteins and is required for the proper temporal control of specific postembryonic cell fates; lin-41 translation is negatively regulated during L4 and adult stages by let-7, a small temporally regulated RNA (stRNA) that is complementary to two sites in the lin-41 3'UTR; LIN-41 is a widely expressed cytoplasmic protein and negatively regulates post-transcriptional expression of LIN-29, a transcription factor required for adult cell fates. |
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Molecular_info (8)
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Experimental_info
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RNAi_result
| Cenix:137-e7
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| | | JA:C12C8.3
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| | | Simmer:C12C8.3:Screen_A
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| | | Simmer:C12C8.3:Screen_B
|
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WB_RNAi_result
| JA:C12C8.3
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| | | Simmer:C12C8.3:Screen_A
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| | | Simmer:C12C8.3:Screen_B
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| | | MV_SV:mv_C12C8.3
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| | | Cenix:137-e7
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Interaction (50)
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Reference (68)
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| Remark | inx-20 and lep-1 has been merged in WS89 and unmerged in WS104 due to SNP mapping evidence. Unmerging also unlinks its other_name opu-20 which is an other_name of inx-20 | Person_evidence | WBPerson178
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| Method | Gene
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