RNAiDB Tree View

Gene: C12C8.3

C12C8.3	Evidence	CGC_data_submission
	SMap	S_parent	Sequence	C12C8
	Chromosome	I
	Identity (5)
	Gene_info	Gene_class	lin
		Allele (6)
		Phenotype	[C.elegansII] ma104 : heterochronic defect in L4/A switch. [VT]
			[Fitch DHA] lep for LEPtoderan tail bx37 male tail tip is pointy and protrudes beyond the posterior edge of the fan. No hermaphrodite phenotype.
			[C.elegansII] bx37sd : male tail tip is pointy and protrudes beyond the posterior edge of the fan, 100%penetrant. No hermaphrodite phenotype. OA1: bx42sd (92% penetrant). [DF]
		Strain	CT8
			MT7897
		GO_term (12)
		Structured_description	Provisional_description	The lin-41 gene encodes a novel RBCC (Ring finger-B box-Coiled coil) protein that is a member of the NHL (NCL-1, HT2A, and LIN-41) family of proteins and is required for the proper temporal control of specific postembryonic cell fates; lin-41 translation is negatively regulated during L4 and adult stages by let-7, a small temporally regulated RNA (stRNA) that is complementary to two sites in the lin-41 3'UTR; LIN-41 is a widely expressed cytoplasmic protein and negatively regulates post-transcriptional expression of LIN-29, a transcription factor required for adult cell fates.	Paper_evidence (4)
					Person_evidence	WBPerson178
						WBPerson1843
					Curator_confirmed	WBPerson1843
					Date_last_updated	08 Aug 2005 00:00:00
				The leptoderan alleles lin-41(bx37) and lin-41(bx42) specifically affect development of the male tail; they cause no defects in the development of alae or in hermaphrodites.
				These two alleles were originally considered to define a new gene (lep-1); they were identified in a screen for mutants with atavistic male tail morphological defects.
			Concise_description	The lin-41 gene encodes a novel RBCC (Ring finger-B box-Coiled coil) protein that is a member of the NHL (NCL-1, HT2A, and LIN-41) family of proteins and is required for the proper temporal control of specific postembryonic cell fates; lin-41 translation is negatively regulated during L4 and adult stages by let-7, a small temporally regulated RNA (stRNA) that is complementary to two sites in the lin-41 3'UTR; LIN-41 is a widely expressed cytoplasmic protein and negatively regulates post-transcriptional expression of LIN-29, a transcription factor required for adult cell fates.
	Molecular_info (8)
	Experimental_info	RNAi_result	Cenix:137-e7
			JA:C12C8.3
			Simmer:C12C8.3:Screen_A
			Simmer:C12C8.3:Screen_B
		WB_RNAi_result (5)
		Interaction (50)
	Reference (68)
	Remark	inx-20 and lep-1 has been merged in WS89 and unmerged in WS104 due to SNP mapping evidence. Unmerging also unlinks its other_name opu-20 which is an other_name of inx-20	Person_evidence	WBPerson178
	Method	Gene