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Gene: C14A4.4   

C14A4.4EvidencePaper_evidenceWBPaper00005857
SMapS_parentSequenceC14A4
ChromosomeII
Identity (5)
Gene_info Gene_classcrn
GO_term GO:0003676 IEA Inferred_automatically
GO:0008408 IEA Inferred_automatically
GO:0005622 IEA Inferred_automatically
Contained_in_operonCEOP2496
Structured_description Provisional_description (5)
Concise_descriptioncrn-3 encodes a cell death-related nuclease, homologous to the 100 kDa polymyositis/scleroderma autoantigen (PM/Scl-100), that is required for normal levels of DNA degradation during apoptosis; PM/Scl-100 is a ribonuclease component of the multiexonuclease exosome complex, which processes or degrades several types of RNAs in yeast; crn-3(RNAi) animals show retarded growth and a low penetrance of embryonic lethality; CRN-3 promotes both DNA degradation and cell corpse engulfment, in a partially redundant pathway that includes CRN-2 but is parallel to CPS-6; CRN-3 is predicted to be mitochondrial.
Molecular_info (5)
Experimental_info RNAi_result Cenix:201-f1
JA:C14A4.4
Simmer:C14A4.4
WB_RNAi_result (5)
InteractionWBInteraction0002092
Reference WBPaper00005857
WBPaper00006283
WBPaper00019408
MethodGene