Gene: C14A4.4
C14A4.4 | Evidence | Paper_evidence | WBPaper00005857 | ||
---|---|---|---|---|---|
SMap | S_parent | Sequence | C14A4 | ||
Chromosome | II | ||||
Identity (5) | |||||
Gene_info | Gene_class | crn | |||
GO_term | GO:0003676 | IEA | Inferred_automatically | ||
GO:0008408 | IEA | Inferred_automatically | |||
GO:0005622 | IEA | Inferred_automatically | |||
Contained_in_operon | CEOP2496 | ||||
Structured_description | Provisional_description (5) | ||||
Concise_description | crn-3 encodes a cell death-related nuclease, homologous to the 100 kDa polymyositis/scleroderma autoantigen (PM/Scl-100), that is required for normal levels of DNA degradation during apoptosis; PM/Scl-100 is a ribonuclease component of the multiexonuclease exosome complex, which processes or degrades several types of RNAs in yeast; crn-3(RNAi) animals show retarded growth and a low penetrance of embryonic lethality; CRN-3 promotes both DNA degradation and cell corpse engulfment, in a partially redundant pathway that includes CRN-2 but is parallel to CPS-6; CRN-3 is predicted to be mitochondrial. | ||||
Molecular_info | Corresponding_CDS | C14A4.4a | |||
C14A4.4b | |||||
Corresponding_protein | WP:CE02145 | ||||
WP:CE32797 | |||||
Corresponding_PCR_product | smd_C14A4.4 | ||||
sjj_C14A4.4 | |||||
Corresponding_RNAi_reagent (5) | |||||
Other_sequence | AY303577 | ||||
Experimental_info | RNAi_result | Cenix:201-f1 | |||
JA:C14A4.4 | |||||
Simmer:C14A4.4 | |||||
WB_RNAi_result (5) | |||||
Interaction | WBInteraction0002092 | ||||
Reference | WBPaper00005857 | ||||
WBPaper00006283 | |||||
WBPaper00019408 | |||||
Method | Gene |