C25D7.3 | SMap | S_parent | Sequence | C25D7
|
| Chromosome | V |
|
Identity (5)
|
|
Gene_info
| Gene_class | sdc
|
| | Reference_allele | y132
|
| |
Allele (10)
|
| | Phenotype | [C.elegansII] y126mat : deletion null, XX animals inviable if mother homozygous; rare escapers dumpy hermaphrodite; cryptic masculinization; XO phenotype WT.OA>10: y122, y127, y143 (similar); also sdc-3 (Tra)alleles: y52 (XX viable, masculinized), y137 (weaker); also sdc-3(Dpy) alleles: y100 (XX inviable or dumpy,no masculinization), y128 etc. Cloned: 7kb transcript present in embryo, L1, L2; encodes 2150 aa protein, possible ATP-binding site (affected in Tra mutations), 2 C-term zinc fingers (affected in Dpy mutations). [DeLong et al. 1993; Klein and Meyer 1993; TY] |
| |
Strain
| BS518
|
| | | TY956
|
| | | TY1077
|
| | | TY1388
|
| |
GO_term (7)
|
| |
Structured_description
|
Provisional_description
| sdc-3 encodes a protein that contains two mutationally separable domains: a zinc finger motif required for dosage compensation and a myosin- like putative ATP- binding region required for her-1 regulation of sex determination; SDC-3 activates dosage compensation by directing the dosage compensation protein complex to the hermaphrodite X chromosomes, and is functionally redundant with SDC-2 with respect to dosage compensation; SDC-1, SDC-2, and SDC-3 proteins form a complex. |
Paper_evidence (5)
|
| | | | | Person_evidence | WBPerson48
|
| | | | | Curator_confirmed | WBPerson48
|
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | | A complex of SDC-1, SDC-2, and SDC-3 proteins is detectable by coimmunoprecipitation; furthermore, SDC-1, SDC-2, and SDC-3 colocalize with DPY-26, DPY-27, and MIX-1 proteins both on a transgenic her-1(+) array and on the X chromosome. |
| | | Concise_description | sdc-3 encodes a protein that contains two mutationally separable domains: a zinc finger motif required for dosage compensation and a myosin- like putative ATP- binding region required for her-1 regulation of sex determination; SDC-3 activates dosage compensation by directing the dosage compensation protein complex to the hermaphrodite X chromosomes, and is functionally redundant with SDC-2 with respect to dosage compensation; SDC-1, SDC-2, and SDC-3 proteins form a complex. |
|
Molecular_info
| Corresponding_CDS | C25D7.3
|
| | Corresponding_protein | WP:CE08389
|
| |
Corresponding_PCR_product
| smd_C25D7.12
|
| | | sjj_C25D7.3
|
| |
Corresponding_RNAi_reagent
| Cenix:55-b5
|
| | | sjj_C25D7.3
|
| | | mv_C25D7.13
|
| |
Gene_product_binds
| WBsf019092
|
| | | WBsf019093
|
|
Experimental_info (5)
|
|
Reference (83)
|
| Method | Gene
|