RNAiDB Tree View

Gene: C25D7.3

C25D7.3	SMap	S_parent	Sequence	C25D7
	Chromosome	V
	Identity (5)
	Gene_info	Gene_class	sdc
		Reference_allele	y132
		Allele (10)
		Phenotype	[C.elegansII] y126mat : deletion null, XX animals inviable if mother homozygous; rare escapers dumpy hermaphrodite; cryptic masculinization; XO phenotype WT.OA>10: y122, y127, y143 (similar); also sdc-3 (Tra)alleles: y52 (XX viable, masculinized), y137 (weaker); also sdc-3(Dpy) alleles: y100 (XX inviable or dumpy,no masculinization), y128 etc. Cloned: 7kb transcript present in embryo, L1, L2; encodes 2150 aa protein, possible ATP-binding site (affected in Tra mutations), 2 C-term zinc fingers (affected in Dpy mutations). [DeLong et al. 1993; Klein and Meyer 1993; TY]
		Strain	BS518
			TY956
			TY1077
			TY1388
		GO_term (7)
		Structured_description	Provisional_description	sdc-3 encodes a protein that contains two mutationally separable domains: a zinc finger motif required for dosage compensation and a myosin- like putative ATP- binding region required for her-1 regulation of sex determination; SDC-3 activates dosage compensation by directing the dosage compensation protein complex to the hermaphrodite X chromosomes, and is functionally redundant with SDC-2 with respect to dosage compensation; SDC-1, SDC-2, and SDC-3 proteins form a complex.	Paper_evidence (5)
					Person_evidence	WBPerson48
					Curator_confirmed	WBPerson48
					Date_last_updated	17 Jun 2004 00:00:00
				A complex of SDC-1, SDC-2, and SDC-3 proteins is detectable by coimmunoprecipitation; furthermore, SDC-1, SDC-2, and SDC-3 colocalize with DPY-26, DPY-27, and MIX-1 proteins both on a transgenic her-1(+) array and on the X chromosome.
			Concise_description	sdc-3 encodes a protein that contains two mutationally separable domains: a zinc finger motif required for dosage compensation and a myosin- like putative ATP- binding region required for her-1 regulation of sex determination; SDC-3 activates dosage compensation by directing the dosage compensation protein complex to the hermaphrodite X chromosomes, and is functionally redundant with SDC-2 with respect to dosage compensation; SDC-1, SDC-2, and SDC-3 proteins form a complex.
	Molecular_info	Corresponding_CDS	C25D7.3
		Corresponding_protein	WP:CE08389
		Corresponding_PCR_product	smd_C25D7.12
			sjj_C25D7.3
		Corresponding_RNAi_reagent	Cenix:55-b5
			sjj_C25D7.3
			mv_C25D7.13
		Gene_product_binds	WBsf019092
			WBsf019093
	Experimental_info (5)
	Reference (83)
	Method	Gene