RNAiDB Tree View

Gene: C32F10.2

C32F10.2	SMap	S_parent	Sequence	C32F10
	Chromosome	I
	Identity (5)
	Gene_info	Gene_class	lin
		Allele	n373
			n745	Inferred_automatically	From strain object: MT1624
					From strain object: MT3033
					From strain object: MT10430
			n2977
		Phenotype	n745 : wildtype alone Muv in homozygotes with lin-8 lin-38 or lin-15(n767). ES2. NA2 (n373 (similar phenotype)).
			See also n373, n745
			[C.elegansII] n745 : almost WT alone (reduced fertility); Muv (extra vulval differentiation) in homozygotes with lin-8, lin-38 or lin-15(n767). ES2. OA1: n373 (similar). [Ferguson and Horvitz 1989; MT; PS]
		Strain	MT1624
			MT3033
			MT10430
		GO_term	GO:0002119	IGI	Paper_evidence	WBPaper00024320
					Curator_confirmed	WBPerson1843
				IMP	Paper_evidence	WBPaper00024320
					Curator_confirmed	WBPerson1843
			GO:0040018	IGI	Paper_evidence	WBPaper00024320
					Curator_confirmed	WBPerson1843
			GO:0000003	IGI	Paper_evidence	WBPaper00024320
					Curator_confirmed	WBPerson1843
				IMP	Paper_evidence	WBPaper00024320
					Curator_confirmed	WBPerson1843
			GO:0009792	IGI	Paper_evidence	WBPaper00024320
					Curator_confirmed	WBPerson1843
		Structured_description	Provisional_description	lin-35 encodes the C. elegans retinoblastoma protein (Rb) ortholog; lin-35 was first identified in screens for synthetic multivulva (synMuv) genes and as a class B synMuv gene, functions redundantly with class A genes to antagonize Ras signaling and negatively regulate vulval development; in addition, lin-35 activity is required redundantly with: 1) pha-1 and ubc-18 for early steps in pharyngeal morphogenesis, 2) fzr-1 for normal patterns of postembryonic proliferation, 3) xnp-1 for somatic gonad development, and 4) psa-1 for fertility and embryonic and larval development; on its own, lin-35 is also required for wild-type levels of fertility; LIN-35 is expressed broadly in embryos and L1 larvae, but in later larvae and adults is detected in vulval precursor cells and their descendants as well as a subset of head and tail cells.	Paper_evidence (8)
					Curator_confirmed	WBPerson1843
					Date_last_updated	20 Sep 2005 00:00:00
				lin-35 encodes the C. elegans retinoblastoma protein (Rb) ortholog; lin-35 was first identified in screens for synthetic multivulva (synMuv) genes and as a class B synMuv gene, functions redundantly with class A genes to antagonize Ras signaling and negatively regulate vulval development; in addition, LIN-35 activity is required redundantly with PHA-1 and UBC-18 for early steps in pharyngeal morphogenesis, with FZR-1 for normal postembryonic development, and with XNP-1 for somatic gonad development; on its own, LIN-35 is also required for wild-type fertility; LIN-35 is expressed broadly in embryos and L1 larvae, and is then detected in vulval precursor cells and their descendants as well as a subset of head and tail cells in later larvae and adults.	Paper_evidence (5)
					Person_evidence	WBPerson1843
			Concise_description	lin-35 encodes the C. elegans retinoblastoma protein (Rb) ortholog; lin-35 was first identified in screens for synthetic multivulva (synMuv) genes and as a class B synMuv gene, functions redundantly with class A genes to antagonize Ras signaling and negatively regulate vulval development; in addition, lin-35 activity is required redundantly with: 1) pha-1 and ubc-18 for early steps in pharyngeal morphogenesis, 2) fzr-1 for normal patterns of postembryonic proliferation, 3) xnp-1 for somatic gonad development, and 4) psa-1 for fertility and embryonic and larval development; on its own, lin-35 is also required for wild-type levels of fertility; LIN-35 is expressed broadly in embryos and L1 larvae, but in later larvae and adults is detected in vulval precursor cells and their descendants as well as a subset of head and tail cells.
				lin-35 encodes the C. elegans retinoblastoma protein (Rb) ortholog; lin-35 was first identified in screens for synthetic multivulva (synMuv) genes and as a class B synMuv gene, functions redundantly with class A genes to antagonize Ras signaling and negatively regulate vulval development; in addition, LIN-35 activity is required redundantly with PHA-1 and UBC-18 for early steps in pharyngeal morphogenesis, with FZR-1 for normal postembryonic development, and with XNP-1 for somatic gonad development; on its own, LIN-35 is also required for wild-type fertility; LIN-35 is expressed broadly in embryos and L1 larvae, and is then detected in vulval precursor cells and their descendants as well as a subset of head and tail cells in later larvae and adults.
	Molecular_info (5)
	Experimental_info (5)
	Reference (97)
	Method	Gene