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Gene: C33F10.9   

C33F10.9SMapS_parentSequenceC33F10
ChromosomeII
Identity (5)
Gene_info Gene_classmsp
Phenotype[C.elegansII] NMK. Encodes MSP (16kD); msp-3 cluster. [Ward et al. (1988); BA]
GO_termGO:0005198 IEA Inferred_automatically
Structured_description Provisional_descriptionmsp-40 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. Paper_evidence WBPaper00001023
WBPaper00002143
WBPaper00004591
WBPaper00005670
Curator_confirmedWBPerson324
Date_last_updated31 Mar 2005 00:00:00
Concise_descriptionmsp-40 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes.
Molecular_info Corresponding_CDSC33F10.9
Corresponding_proteinWP:CE02806
Corresponding_PCR_product (18)
Corresponding_RNAi_reagent Cenix:203-f3
sjj_C33F10.9
sjj_R05F9.8
sjj_F32B6.6
sjj_F58A6.8
sjj_R05F9.3
sjj_ZK546.6
sjj_F26G1.7
Cenix:246-b8
sjj_ZK546.3
mv_F26G1.7
Cenix:211-g4
sjj_R05F9.13
Cenix:205-e12
mv_ZK546.6
sjj_T13F2.10
Cenix:13-f11
sjj_F09C12.7
mv_R05F9.8
mv_C33F10.9
yk370d1
mv_F32B6.6
Cenix:242-g7
Experimental_info RNAi_result Cenix:203-f3
JA:C33F10.9
WB_RNAi_result (81)
Expr_patternExpr3417
Reference WBPaper00001023
WBPaper00015440
WBPaper00024312
WBPaper00025088
MethodGene