C34C6.6 | SMap | S_parent | Sequence | C34C6
|
| Chromosome | II |
|
Identity (5)
|
|
Gene_info
| Gene_class | prx
|
| | GO_term | GO:0005488
| IEA
| Inferred_automatically |
| |
Structured_description
|
Provisional_description
| prx-5 encodes an ortholog of the human receptor for type I peroxisomal targeting signal protein, PXR1 (or PEX5; OMIM:600414), which when mutated leads to neonatal adrenoleukodystrophy or Zellweger syndrome; PXR1 protein is a component of the peroxisomal import machinery known to exist in organisms like yeast, plants and mammals. | Paper_evidence | WBPaper00004395
|
| | | | | Person_evidence | WBPerson567
|
| | | | | Curator_confirmed | WBPerson567
|
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | | Peroxisomal diseases in humans often lead to degeneration or poor development of neurons; for example, Zellweger Syndrome represents a class of peroxisomal biogenesis disorders in which the entire peroxisomal compartment is compromised and is associated with severe neurological impairments. |
| | | | PRX-5 protein interacts strongly in a two-hybrid assay with Gal4p-SKL, indicating that the eukaryotic PRX5-dependent route for importing PTS1-containing proteins into peroxisomes is conserved in nematodes; furthermore, a screen using PRX-5 identified interaction partners which appear likely to be peroxisomal proteins. |
| | | Concise_description | prx-5 encodes an ortholog of the human receptor for type I peroxisomal targeting signal protein, PXR1 (or PEX5; OMIM:600414), which when mutated leads to neonatal adrenoleukodystrophy or Zellweger syndrome; PXR1 protein is a component of the peroxisomal import machinery known to exist in organisms like yeast, plants and mammals. |
|
Molecular_info
|
Corresponding_CDS
| C34C6.6a
|
| | | C34C6.6b
|
| |
Corresponding_protein
| WP:CE03054
|
| | | WP:CE36377
|
| |
Corresponding_PCR_product
| smd_C34C6.6
|
| | | sjj_C34C6.6
|
| |
Corresponding_RNAi_reagent
| Cenix:20-c12
|
| | | sjj_C34C6.6
|
| | | [pmid12181365]:PXR1
|
| | | mv_C34C6.6
|
|
Experimental_info
|
RNAi_result (8)
|
| |
WB_RNAi_result (9)
|
| |
Y2H_target (36)
|
| Reference | WBPaper00005877
|
|
Remark
| Sequence connection from [Motley AM, Plasterk RHA], 02/06/13 krb. |
| | Note that some Authors have incorrectly published prx genes as pex genes. pex genes are a separate class of gene not related to prx genes[JAH][030108 ck1] |
| Method | Gene
|