RNAiDB Tree View

Gene: C34C6.6

C34C6.6	SMap	S_parent	Sequence	C34C6
	Chromosome	II
	Identity (5)
	Gene_info	Gene_class	prx
		GO_term	GO:0005488	IEA	Inferred_automatically
		Structured_description	Provisional_description	prx-5 encodes an ortholog of the human receptor for type I peroxisomal targeting signal protein, PXR1 (or PEX5; OMIM:600414), which when mutated leads to neonatal adrenoleukodystrophy or Zellweger syndrome; PXR1 protein is a component of the peroxisomal import machinery known to exist in organisms like yeast, plants and mammals.	Paper_evidence	WBPaper00004395
					Person_evidence	WBPerson567
					Curator_confirmed	WBPerson567
					Date_last_updated	17 Jun 2004 00:00:00
				Peroxisomal diseases in humans often lead to degeneration or poor development of neurons; for example, Zellweger Syndrome represents a class of peroxisomal biogenesis disorders in which the entire peroxisomal compartment is compromised and is associated with severe neurological impairments.
				PRX-5 protein interacts strongly in a two-hybrid assay with Gal4p-SKL, indicating that the eukaryotic PRX5-dependent route for importing PTS1-containing proteins into peroxisomes is conserved in nematodes; furthermore, a screen using PRX-5 identified interaction partners which appear likely to be peroxisomal proteins.
			Concise_description	prx-5 encodes an ortholog of the human receptor for type I peroxisomal targeting signal protein, PXR1 (or PEX5; OMIM:600414), which when mutated leads to neonatal adrenoleukodystrophy or Zellweger syndrome; PXR1 protein is a component of the peroxisomal import machinery known to exist in organisms like yeast, plants and mammals.
	Molecular_info	Corresponding_CDS	C34C6.6a
			C34C6.6b
		Corresponding_protein	WP:CE03054
			WP:CE36377
		Corresponding_PCR_product	smd_C34C6.6
			sjj_C34C6.6
		Corresponding_RNAi_reagent	Cenix:20-c12
			sjj_C34C6.6
			[pmid12181365]:PXR1
			mv_C34C6.6
	Experimental_info	RNAi_result (8)
		WB_RNAi_result	[pmid12181365]:PXR1
			JA:C34C6.6
			[cgc5655]:C34C6.6
			[cgc5655]:daf-2:C34C6.6
			[cgc5655]:tph-1:C34C6.6
			[cgc5655]:tub-1:C34C6.6
			Simmer:C34C6.6
			MV_SV:mv_C34C6.6
			Cenix:20-c12
		Y2H_target (36)
	Reference	WBPaper00005877
	Remark	Sequence connection from [Motley AM, Plasterk RHA], 02/06/13 krb.
		Note that some Authors have incorrectly published prx genes as pex genes. pex genes are a separate class of gene not related to prx genes[JAH][030108 ck1]
	Method	Gene