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Gene: C34C6.6   

C34C6.6SMapS_parentSequenceC34C6
ChromosomeII
Identity (5)
Gene_info Gene_classprx
GO_termGO:0005488 IEA Inferred_automatically
Structured_description Provisional_description prx-5 encodes an ortholog of the human receptor for type I peroxisomal targeting signal protein, PXR1 (or PEX5; OMIM:600414), which when mutated leads to neonatal adrenoleukodystrophy or Zellweger syndrome; PXR1 protein is a component of the peroxisomal import machinery known to exist in organisms like yeast, plants and mammals.Paper_evidenceWBPaper00004395
Person_evidenceWBPerson567
Curator_confirmedWBPerson567
Date_last_updated17 Jun 2004 00:00:00
Peroxisomal diseases in humans often lead to degeneration or poor development of neurons; for example, Zellweger Syndrome represents a class of peroxisomal biogenesis disorders in which the entire peroxisomal compartment is compromised and is associated with severe neurological impairments.
PRX-5 protein interacts strongly in a two-hybrid assay with Gal4p-SKL, indicating that the eukaryotic PRX5-dependent route for importing PTS1-containing proteins into peroxisomes is conserved in nematodes; furthermore, a screen using PRX-5 identified interaction partners which appear likely to be peroxisomal proteins.
Concise_descriptionprx-5 encodes an ortholog of the human receptor for type I peroxisomal targeting signal protein, PXR1 (or PEX5; OMIM:600414), which when mutated leads to neonatal adrenoleukodystrophy or Zellweger syndrome; PXR1 protein is a component of the peroxisomal import machinery known to exist in organisms like yeast, plants and mammals.
Molecular_info Corresponding_CDS C34C6.6a
C34C6.6b
Corresponding_protein WP:CE03054
WP:CE36377
Corresponding_PCR_product smd_C34C6.6
sjj_C34C6.6
Corresponding_RNAi_reagent Cenix:20-c12
sjj_C34C6.6
[pmid12181365]:PXR1
mv_C34C6.6
Experimental_info RNAi_result (8)
WB_RNAi_result (9)
Y2H_target Y2H000350
Y2H000351
Y2H000352
Y2H000353
Y2H000354
Y2H000356
Y2H000357
Y2H000359
Y2H000439
Y2H000440
Y2H000441
Y2H000442
Y2H000446
Y2H000448
Y2H000451
Y2H000452
Y2H000453
Y2H000455
Y2H000498
Y2H000499
Y2H000500
Y2H000501
Y2H004135
Y2H004139
Y2H004158
Y2H006284
Y2H006285
Y2H006287
Y2H006288
Y2H006290
Y2H006293
Y2H006294
Y2H006295
Y2H006342
Y2H006343
Y2H010407
ReferenceWBPaper00005877
Remark Sequence connection from [Motley AM, Plasterk RHA], 02/06/13 krb.
Note that some Authors have incorrectly published prx genes as pex genes. pex genes are a separate class of gene not related to prx genes[JAH][030108 ck1]
MethodGene