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Gene: C34F11.6   

C34F11.6SMapS_parentSequenceC34F11
ChromosomeII
Identity (5)
Gene_info Gene_classmsp
Phenotype[C.elegansII] NMK. Encodes MSP (16kD); msp-45 cluster. [Ward et al. (1988); BA]
GO_termGO:0005198 IEA Inferred_automatically
Structured_description Provisional_descriptionmsp-49 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. Paper_evidence WBPaper00001023
WBPaper00002143
WBPaper00004591
WBPaper00005670
Curator_confirmedWBPerson324
Date_last_updated31 Mar 2005 00:00:00
Concise_descriptionmsp-49 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes.
Molecular_info Corresponding_CDSC34F11.6
Corresponding_proteinWP:CE04166
Corresponding_PCR_product (39)
Corresponding_RNAi_reagent Cenix:203-f6
sjj_C34F11.6
mv_ZK354.4
sjj_ZK354.11
sjj_R05F9.8
Cenix:14-e7
sjj_C34F11.4
Cenix:13-d1
sjj_R13H9.2
sjj_ZK354.1
mv_C34F11.4
sjj_F36H12.7
sjj_F58A6.8
sjj_R05F9.3
mv_F36H12.7
mv_C34F11.6
sjj_F26G1.7
Cenix:246-b8
sjj_ZK546.3
yk380e3
Cenix:242-c6
sjj_Y59E9_120.c
Cenix:242-h2
mv_C09B9.6
mv_F26G1.7
Cenix:211-g4
sjj_R05F9.13
Cenix:205-e12
Cenix:245-g4
sjj_Y4C6A.c
Cenix:13-f11
sjj_F09C12.7
Cenix:13-d7
sjj_R13H9.4
mv_R05F9.8
sjj_C09B9.6
sjj_ZK354.5
sjj_ZK354.4
Experimental_info RNAi_result Cenix:203-f6
JA:C34F11.6
WB_RNAi_result (64)
Expr_patternExpr3417
Reference WBPaper00001023
WBPaper00024312
MethodGene