RNAiDB Tree View

Gene: C37F5.1

C37F5.1	SMap	S_parent	Sequence	SUPERLINK_RW4
	Chromosome	IV
	Identity (5)
	Gene_info	Gene_class	lin
		Reference_allele	e1777
		Allele (66)
		Phenotype	e1777amber : adult hermaphrodite has multiple (one to four) vulval protrusions often bursts at abnormal vulva during L4 molt; ES3 (adult)/ ES1 (larvae); HME2; adult male has redimentary ectopic hooks ES1 ME0. NA16 (e1026 n431amber (phenotype resembles e1777) e1275 (weaker slightly ts phenotype ME1) etc.).
			See also e1026, e1275, e1777, n176, n303, n304, n381, n383, n430, n431, n746, n753, n757, n1047, n1054, n1140, n1141
			[Beitel G and Tuck S] e1777, although an amber mutation, is not NULL.	Paper_evidence	WBPaper00002125
					WBPaper00002352
			[C.elegansII] e1777amb : adult hermaphrodite has multiple (one to four) vulval protrusions, often bursts at abnormal vulva during L4 molt; ES3 (adult)/ ES1 (larvae); HME2; adult male has rudimentary ectopic hooks ES1 ME0. OA>20: e1026, n431amb (phenotype resembles e1777), e1275 (weaker, slightly ts phenotype; ME1), n746, n1141 etc. Cloned: encodes predicted protein with strong similarity to ETS family transcription factors. [Ferguson et al. 1985; Katz et al. 1995; GS; MT]
		Strain (22)
		GO_term (6)
		Structured_description	Provisional_description	lin-1 encodes an Ets-domain-containing transcription factor that is a member of the ETS gene family that includes human ELK1, 3, and 4 (OMIM:600247); LIN-1 functions as a general effector of MAP kinase-mediated signaling; when MAP kinase is inactive, LIN-1 forms a complex with LIN-31/WH that inhibits vulval cell fate specification; upon MAP kinase activation (vulval induction), LIN-1 is phosphorylated, dissociates from LIN-31, and becomes inactive, thus allowing for vulval development.	Paper_evidence	WBPaper00003087
						WBPaper00005344
					Person_evidence	WBPerson1843
					Curator_confirmed	WBPerson1843
					Date_last_updated	17 Jun 2004 00:00:00
			Concise_description	lin-1 encodes an Ets-domain-containing transcription factor that is a member of the ETS gene family that includes human ELK1, 3, and 4 (OMIM:600247); LIN-1 functions as a general effector of MAP kinase-mediated signaling; when MAP kinase is inactive, LIN-1 forms a complex with LIN-31/WH that inhibits vulval cell fate specification; upon MAP kinase activation (vulval induction), LIN-1 is phosphorylated, dissociates from LIN-31, and becomes inactive, thus allowing for vulval development.
	Molecular_info (7)
	Experimental_info	RNAi_result (5)
		WB_RNAi_result (7)
		Interaction (32)
	Reference (170)
	Method	Gene