RNAiDB Tree View

Gene: C38C10.4

C38C10.4	Evidence	CGC_data_submission
	SMap	S_parent	Sequence	C38C10
	Chromosome	III
	Identity (5)
	Gene_info	Gene_class	gpr
		Allele	ok1179	Inferred_automatically	From strain object: RB1150
			tm964
		Strain	RB1150
		GO_term	GO:0005096	IEA	Inferred_automatically
			GO:0007165	IEA	Inferred_automatically
			GO:0005488	IEA	Inferred_automatically
		Contained_in_operon	CEOP3576
		Structured_description	Provisional_description	gpr-2 encodes a protein containing a GPR (G Protein Regulator)/GoLoco motif characteristic of guanine nucleotide exchange factors specific for G-alpha GTPases; GPR-2 appears to function redundantly during early embryogenesis and germ-line development to regulate chromosome and spindle movements during cell division; GPR-2 likely acts as a positive regulator of G protein signaling and specifically, may regulate GOA-1 signaling in the embryo; GPR-2 forms a protein complex with the nearly identical GPR-1 and with LIN-5, a coiled-coil protein that is required for proper localization of GPR-2 to the cell cortex and spindle asters of the early embryo; in addition, proper GPR-2/GPR-1/LIN-5 localization between the P2 and EMS blastomeres at the four-cell stage, which may contribute to spindle positioning in EMS, requires the MES-1/SRC-1 tyrosine kinase signaling pathway; GPR-2 is believed to act downstream of, or in parallel to, PAR-3, a PDZ domain-containing protein, in mitotic spindle positioning in the early embryo.	Paper_evidence	WBPaper00005405
						WBPaper00005878
						WBPaper00017879
					Person_evidence	WBPerson1843
					Curator_confirmed	WBPerson1843
					Date_last_updated	17 Jun 2004 00:00:00
			Concise_description	gpr-2 encodes a protein containing a GPR (G Protein Regulator)/GoLoco motif characteristic of guanine nucleotide exchange factors specific for G-alpha GTPases; GPR-2 appears to function redundantly during early embryogenesis and germ-line development to regulate chromosome and spindle movements during cell division; GPR-2 likely acts as a positive regulator of G protein signaling and specifically, may regulate GOA-1 signaling in the embryo; GPR-2 forms a protein complex with the nearly identical GPR-1 and with LIN-5, a coiled-coil protein that is required for proper localization of GPR-2 to the cell cortex and spindle asters of the early embryo; in addition, proper GPR-2/GPR-1/LIN-5 localization between the P2 and EMS blastomeres at the four-cell stage, which may contribute to spindle positioning in EMS, requires the MES-1/SRC-1 tyrosine kinase signaling pathway; GPR-2 is believed to act downstream of, or in parallel to, PAR-3, a PDZ domain-containing protein, in mitotic spindle positioning in the early embryo.
	Molecular_info	Corresponding_CDS	C38C10.4
		Corresponding_protein	WP:CE00107
		Corresponding_PCR_product (5)
		Corresponding_RNAi_reagent (8)
	Experimental_info	RNAi_result (5)
		WB_RNAi_result (8)
		Expr_pattern	Expr2564
		Gene_regulation	Trans_target	pmid12730122_gpr
	Reference (17)
	Remark	Sequence connection from [Ahringer JA]
		Gene renamed from ags-3.3 to gpr-2 following advice from [Hodgkin J], [020808 krb]
		Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.	CGC_data_submission
	Method	Gene