RNAiDB Tree View

Gene: C43E11.6

C43E11.6	Evidence	CGC_data_submission
	SMap	S_parent	Sequence	C43E11
	Chromosome	I
	Identity (5)
	Gene_info	Gene_class	nab
		Allele (5)
		Strain	RB1017
			VC284
		GO_term	GO:0005515	IEA	Inferred_automatically
		Contained_in_operon	CEOP1156
		Structured_description	Provisional_description	nab-1 encodes a PDZ and SAM domain-containing protein that is the sole C. elegans ortholog of the mammalian Neurabin/Spinophilin proteins; by homology, NAB-1 is predicted to interact with F-actin, ZYG-8/Doublecortin and the SAD-1 serine/threonine kinase to regulate interactions between the actin and microtubule networks during cell migration, growth cone guidance, and cell division; loss of nab-1 activity via RNAi has been reported to result in early embryonic lethality, dumpy and left-handed roller animals, as well as abnormalities in germ-line development and vulval morphogenesis; in large-scale screens, nab-1 RNAi did not result in any obvious abnormalities; NAB-1 translational reporter fusions show expression in hypodermal cells, neurons, and muscle.	Paper_evidence (5)
					Person_evidence	WBPerson1843
					Curator_confirmed	WBPerson1843
					Date_last_updated	18 Jan 2005 00:00:00
			Concise_description	nab-1 encodes a PDZ and SAM domain-containing protein that is the sole C. elegans ortholog of the mammalian Neurabin/Spinophilin proteins; by homology, NAB-1 is predicted to interact with F-actin, ZYG-8/Doublecortin and the SAD-1 serine/threonine kinase to regulate interactions between the actin and microtubule networks during cell migration, growth cone guidance, and cell division; loss of nab-1 activity via RNAi has been reported to result in early embryonic lethality, dumpy and left-handed roller animals, as well as abnormalities in germ-line development and vulval morphogenesis; in large-scale screens, nab-1 RNAi did not result in any obvious abnormalities; NAB-1 translational reporter fusions show expression in hypodermal cells, neurons, and muscle.
	Molecular_info	Corresponding_CDS (5)
		Corresponding_protein (5)
		Corresponding_PCR_product	smd_C43E11.6
			sjj_C43E11.6
		Corresponding_RNAi_reagent	Cenix:146-g6
			sjj_C43E11.6
			mv_C43E11.6
	Experimental_info	RNAi_result (6)
		WB_RNAi_result (7)
		Y2H_target	Y2H009781
	Reference (5)
	Remark	Sequence connection from [Gleason M, Miller DM]
		Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.	CGC_data_submission
	Method	Gene