Gene: C45G3.1   

C45G3.1	SMap	S_parent	Sequence	C45G3
	Chromosome	I
	Identity (5)
	Gene_info	Gene_class	tag
		Allele	ok1208	Inferred_automatically	From strain object: VC761
		Strain	VC761
		Structured_description	Provisional_description (8)
			Concise_description	The C45G3.1 gene encodes a protein, with one N-terminal calponin-like actin-binding domain and two IQ calmodulin-binding domains, that is likely to be required for spindle structure and function, and (indirectly) for neural function, based on its orthology to Drosophila ABNORMAL SPINDLE and on its joint sterile and uncoordinated RNAi phenotypes; C45G3.1 is also orthologous to human ASPM (OMIM:605481), which when mutated leads to primary microcephaly; C45G3.1 is required for embryonic and larval viability, germline maintenance, vulval morphogenesis, meiosis, and locomotion.
	Molecular_info (5)
	Experimental_info	RNAi_result (5)
		WB_RNAi_result (6)
		Expr_pattern	Expr2028
		Y2H_bait (11)
	Remark	Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.	CGC_data_submission
	Method	Gene

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