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Gene: C47D12.8   

C47D12.8SMapS_parentSequenceSUPERLINK_CB_II
ChromosomeII
Identity (5)
Gene_info Allele uCE2-2026
uCE2-2027
GO_term GO:0003676 IEA Inferred_automatically
GO:0004518 IEA Inferred_automatically
GO:0006259 IEA Inferred_automatically
Contained_in_operonCEOP2572
Structured_description Provisional_description C47D12.8 encodes an ortholog of the DNA repair protein XPF/ERCC4, which when mutated in humans leads to xeroderma pigmentosum (complementation group F; OMIM:133520); C47D12.8(RNAi) animals are hypersensitive to ultraviolet radiation, with increased germ cell apoptosis and embryonic lethality; C47D12.8 protein interacts with F10G8.7 (an ERCC1 ortholog) in yeast two-hybrid assays; C47D12.8 is expressed broadly in both embryonic and postembryonic animals, and is required for embryonic development; C47D12.8 is upregulated in dauers, and shares an operon with kel-1 and VF13D12L.3. Paper_evidence WBPaper00004805
WBPaper00005039
WBPaper00024359
WBPaper00024497
Curator_confirmedWBPerson567
Date_last_updated18 Jul 2005 00:00:00
C47D12.8 is orthologous to the human gene DNA REPAIR PROTEIN (ERCC4; OMIM:133520), which when mutated leads to disease.Person_evidenceWBPerson567
Concise_description C47D12.8 encodes an ortholog of the DNA repair protein XPF/ERCC4, which when mutated in humans leads to xeroderma pigmentosum (complementation group F; OMIM:133520); C47D12.8(RNAi) animals are hypersensitive to ultraviolet radiation, with increased germ cell apoptosis and embryonic lethality; C47D12.8 protein interacts with F10G8.7 (an ERCC1 ortholog) in yeast two-hybrid assays; C47D12.8 is expressed broadly in both embryonic and postembryonic animals, and is required for embryonic development; C47D12.8 is upregulated in dauers, and shares an operon with kel-1 and VF13D12L.3.
C47D12.8 is orthologous to the human gene DNA REPAIR PROTEIN (ERCC4; OMIM:133520), which when mutated leads to disease.
Molecular_info (5)
Experimental_info RNAi_result Cenix:200-h3
JA:C47D12.8
WB_RNAi_result JA:C47D12.8
MV_SV:mv_VF13D12L.2
Cenix:200-h3
Expr_pattern Expr3076
Expr6184
MethodGene