C47D12.8 | SMap | S_parent | Sequence | SUPERLINK_CB_II
|
| Chromosome | II |
|
Identity (5)
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|
Gene_info
|
Allele
| uCE2-2026
|
| | | uCE2-2027
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| |
GO_term
| GO:0003676
| IEA
| Inferred_automatically |
| | | GO:0004518
| IEA
| Inferred_automatically |
| | | GO:0006259
| IEA
| Inferred_automatically |
| | Contained_in_operon | CEOP2572
|
| |
Structured_description
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Provisional_description
| C47D12.8 encodes an ortholog of the DNA repair protein XPF/ERCC4, which when mutated in humans leads to xeroderma pigmentosum (complementation group F; OMIM:133520); C47D12.8(RNAi) animals are hypersensitive to ultraviolet radiation, with increased germ cell apoptosis and embryonic lethality; C47D12.8 protein interacts with F10G8.7 (an ERCC1 ortholog) in yeast two-hybrid assays; C47D12.8 is expressed broadly in both embryonic and postembryonic animals, and is required for embryonic development; C47D12.8 is upregulated in dauers, and shares an operon with kel-1 and VF13D12L.3. |
Paper_evidence
| WBPaper00004805
|
| | | | | | WBPaper00005039
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| | | | | | WBPaper00024359
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| | | | | | WBPaper00024497
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| | | | | Curator_confirmed | WBPerson567
|
| | | | | Date_last_updated | 18 Jul 2005 00:00:00 |
| | | | C47D12.8 is orthologous to the human gene DNA REPAIR PROTEIN (ERCC4; OMIM:133520), which when mutated leads to disease. | Person_evidence | WBPerson567
|
| | |
Concise_description
| C47D12.8 encodes an ortholog of the DNA repair protein XPF/ERCC4, which when mutated in humans leads to xeroderma pigmentosum (complementation group F; OMIM:133520); C47D12.8(RNAi) animals are hypersensitive to ultraviolet radiation, with increased germ cell apoptosis and embryonic lethality; C47D12.8 protein interacts with F10G8.7 (an ERCC1 ortholog) in yeast two-hybrid assays; C47D12.8 is expressed broadly in both embryonic and postembryonic animals, and is required for embryonic development; C47D12.8 is upregulated in dauers, and shares an operon with kel-1 and VF13D12L.3. |
| | | | C47D12.8 is orthologous to the human gene DNA REPAIR PROTEIN (ERCC4; OMIM:133520), which when mutated leads to disease. |
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Molecular_info (5)
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Experimental_info
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RNAi_result (2)
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| |
WB_RNAi_result
| JA:C47D12.8
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| | | MV_SV:mv_VF13D12L.2
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| | | Cenix:200-h3
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| |
Expr_pattern
| Expr3076
|
| | | Expr6184
|
| Method | Gene
|