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Gene: C55B7.8   

C55B7.8SMapS_parentSequenceC55B7
ChromosomeI
Identity Version1
Name (7)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:22WBPerson1971 EventImportedInitial conversion from geneace
StatusLive
Gene_info Gene_classdbr
GO_term (7)
Contained_in_operonCEOP1324
Structured_description Provisional_descriptiondbr-1 encodes a homolog of the RNA lariat-debranching enzyme; DBR-1 is predicted to function in RNA processing by hydrolyzing the 2'-5' phosphodiester bond at the branchpoint of excised lariat intron RNA, thus converting the introns into linear molecules that can subsequently be degraded by exonucleases; in C. elegans, DBR-1 activity is required for embryonic and germline development, as well as for normal rates of postembryonic growth; overexpression of C. elegans DBR-1 in Saccharomyces cerevisiae can complement the RNA processing defects of a dbr1 null mutant strain, restoring debranching activity and intron degradation to near wild-type levels.Paper_evidenceWBPaper00002739
Person_evidenceWBPerson1843
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
Concise_descriptiondbr-1 encodes a homolog of the RNA lariat-debranching enzyme; DBR-1 is predicted to function in RNA processing by hydrolyzing the 2'-5' phosphodiester bond at the branchpoint of excised lariat intron RNA, thus converting the introns into linear molecules that can subsequently be degraded by exonucleases; in C. elegans, DBR-1 activity is required for embryonic and germline development, as well as for normal rates of postembryonic growth; overexpression of C. elegans DBR-1 in Saccharomyces cerevisiae can complement the RNA processing defects of a dbr1 null mutant strain, restoring debranching activity and intron degradation to near wild-type levels.
Molecular_info (6)
Experimental_info RNAi_result (5)
WB_RNAi_result (5)
ReferenceWBPaper00002739
MethodGene