Go to RNAiDB Home Adult Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie
 

Gene: C55B7.8   

C55B7.8SMapS_parentSequenceC55B7
ChromosomeI
Identity (5)
Gene_info Gene_classdbr
GO_term GO:0016788 IEA Inferred_automatically
GO:0006397 IEA Inferred_automatically
GO:0016787 IEA Inferred_automatically
GO:0003735 IEA Inferred_automatically
GO:0006412 IEA Inferred_automatically
GO:0005622 IEA Inferred_automatically
GO:0005840 IEA Inferred_automatically
Contained_in_operonCEOP1324
Structured_description Provisional_descriptiondbr-1 encodes a homolog of the RNA lariat-debranching enzyme; DBR-1 is predicted to function in RNA processing by hydrolyzing the 2'-5' phosphodiester bond at the branchpoint of excised lariat intron RNA, thus converting the introns into linear molecules that can subsequently be degraded by exonucleases; in C. elegans, DBR-1 activity is required for embryonic and germline development, as well as for normal rates of postembryonic growth; overexpression of C. elegans DBR-1 in Saccharomyces cerevisiae can complement the RNA processing defects of a dbr1 null mutant strain, restoring debranching activity and intron degradation to near wild-type levels.Paper_evidenceWBPaper00002739
Person_evidenceWBPerson1843
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
Concise_descriptiondbr-1 encodes a homolog of the RNA lariat-debranching enzyme; DBR-1 is predicted to function in RNA processing by hydrolyzing the 2'-5' phosphodiester bond at the branchpoint of excised lariat intron RNA, thus converting the introns into linear molecules that can subsequently be degraded by exonucleases; in C. elegans, DBR-1 activity is required for embryonic and germline development, as well as for normal rates of postembryonic growth; overexpression of C. elegans DBR-1 in Saccharomyces cerevisiae can complement the RNA processing defects of a dbr1 null mutant strain, restoring debranching activity and intron degradation to near wild-type levels.
Molecular_info (6)
Experimental_info RNAi_result Cenix:146-c8
JA:C55B7.8
PF:GL1_6E10
Simmer:C55B7.8:Screen_A
Simmer:C55B7.8:Screen_B
WB_RNAi_result (5)
ReferenceWBPaper00002739
MethodGene