Gene: C55B7.8
C55B7.8 | SMap | S_parent | Sequence | C55B7 | ||
---|---|---|---|---|---|---|
Chromosome | I | |||||
Identity (5) | ||||||
Gene_info | Gene_class | dbr | ||||
GO_term | GO:0016788 | IEA | Inferred_automatically | |||
GO:0006397 | IEA | Inferred_automatically | ||||
GO:0016787 | IEA | Inferred_automatically | ||||
GO:0003735 | IEA | Inferred_automatically | ||||
GO:0006412 | IEA | Inferred_automatically | ||||
GO:0005622 | IEA | Inferred_automatically | ||||
GO:0005840 | IEA | Inferred_automatically | ||||
Contained_in_operon | CEOP1324 | |||||
Structured_description | Provisional_description | dbr-1 encodes a homolog of the RNA lariat-debranching enzyme; DBR-1 is predicted to function in RNA processing by hydrolyzing the 2'-5' phosphodiester bond at the branchpoint of excised lariat intron RNA, thus converting the introns into linear molecules that can subsequently be degraded by exonucleases; in C. elegans, DBR-1 activity is required for embryonic and germline development, as well as for normal rates of postembryonic growth; overexpression of C. elegans DBR-1 in Saccharomyces cerevisiae can complement the RNA processing defects of a dbr1 null mutant strain, restoring debranching activity and intron degradation to near wild-type levels. | Paper_evidence | WBPaper00002739 | ||
Person_evidence | WBPerson1843 | |||||
Curator_confirmed | WBPerson1843 | |||||
Date_last_updated | 17 Jun 2004 00:00:00 | |||||
Concise_description | dbr-1 encodes a homolog of the RNA lariat-debranching enzyme; DBR-1 is predicted to function in RNA processing by hydrolyzing the 2'-5' phosphodiester bond at the branchpoint of excised lariat intron RNA, thus converting the introns into linear molecules that can subsequently be degraded by exonucleases; in C. elegans, DBR-1 activity is required for embryonic and germline development, as well as for normal rates of postembryonic growth; overexpression of C. elegans DBR-1 in Saccharomyces cerevisiae can complement the RNA processing defects of a dbr1 null mutant strain, restoring debranching activity and intron degradation to near wild-type levels. | |||||
Molecular_info (6) | ||||||
Experimental_info | RNAi_result | Cenix:146-c8 | ||||
JA:C55B7.8 | ||||||
PF:GL1_6E10 | ||||||
Simmer:C55B7.8:Screen_A | ||||||
Simmer:C55B7.8:Screen_B | ||||||
WB_RNAi_result (5) | ||||||
Reference | WBPaper00002739 | |||||
Method | Gene |