C55B7.8 | SMap | S_parent | Sequence | C55B7
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| Chromosome | I |
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Identity (5)
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Gene_info
| Gene_class | dbr
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GO_term (7)
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| | Contained_in_operon | CEOP1324
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Structured_description
| Provisional_description | dbr-1 encodes a homolog of the RNA lariat-debranching enzyme; DBR-1 is predicted to function in RNA processing by hydrolyzing the 2'-5' phosphodiester bond at the branchpoint of excised lariat intron RNA, thus converting the introns into linear molecules that can subsequently be degraded by exonucleases; in C. elegans, DBR-1 activity is required for embryonic and germline development, as well as for normal rates of postembryonic growth; overexpression of C. elegans DBR-1 in Saccharomyces cerevisiae can complement the RNA processing defects of a dbr1 null mutant strain, restoring debranching activity and intron degradation to near wild-type levels. | Paper_evidence | WBPaper00002739
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| | | | | Person_evidence | WBPerson1843
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| | | | | Curator_confirmed | WBPerson1843
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| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Concise_description | dbr-1 encodes a homolog of the RNA lariat-debranching enzyme; DBR-1 is predicted to function in RNA processing by hydrolyzing the 2'-5' phosphodiester bond at the branchpoint of excised lariat intron RNA, thus converting the introns into linear molecules that can subsequently be degraded by exonucleases; in C. elegans, DBR-1 activity is required for embryonic and germline development, as well as for normal rates of postembryonic growth; overexpression of C. elegans DBR-1 in Saccharomyces cerevisiae can complement the RNA processing defects of a dbr1 null mutant strain, restoring debranching activity and intron degradation to near wild-type levels. |
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Molecular_info
| Corresponding_CDS | C55B7.8
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| | Corresponding_protein | WP:CE30437
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| | KOG | KOG2863
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| | Corresponding_PCR_product | sjj_C55B7.8
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Corresponding_RNAi_reagent
| Cenix:146-c8
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| | | sjj_C55B7.8
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| | Other_sequence | U63636
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Experimental_info
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RNAi_result
| Cenix:146-c8
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| | | JA:C55B7.8
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| | | PF:GL1_6E10
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| | | Simmer:C55B7.8:Screen_A
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| | | Simmer:C55B7.8:Screen_B
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WB_RNAi_result (5)
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| Reference | WBPaper00002739
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| Method | Gene
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